对人类角化棘皮瘤的免疫反应。

Immune response to human keratoacanthoma.

作者信息

Flannery G R, Muller H K

出版信息

Br J Dermatol. 1979 Dec;101(6):625-32. doi: 10.1111/j.1365-2133.1979.tb05640.x.

DOI:10.1111/j.1365-2133.1979.tb05640.x

Abstract

Immune reactivity to human keratoacanthoma was investigated by microcytotoxicity tests and immunofluorescence. IgM and complement were consistently present in lesions; IgG and fibrin were infrequent. No evidence of in vivo bound immunoglobulin was found on the surface of keratoacanthoma cells by membrane immunofluorescence. Neither patients' sera nor peripheral blood leukocytes showed significant cytotoxicity against autochthonous tumour cells in microtitre assays. This study fails to support the view that regression of human keratoacanthoma is mediated by immunological mechanisms.

摘要

通过微量细胞毒性试验和免疫荧光法研究了对人角化棘皮瘤的免疫反应性。病变中始终存在IgM和补体；IgG和纤维蛋白很少见。通过膜免疫荧光法未在角化棘皮瘤细胞表面发现体内结合免疫球蛋白的证据。在微量滴定试验中，患者血清和外周血白细胞均未显示出对自身肿瘤细胞的明显细胞毒性。这项研究不支持人角化棘皮瘤的消退是由免疫机制介导的观点。