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一位母亲患脉络膜恶性黑色素瘤,其儿子患视网膜母细胞瘤。

Malignant melanoma of the choroid in a mother and retinoblastoma in her son.

作者信息

Hayasaka S, Mizuno K

出版信息

Br J Ophthalmol. 1986 Feb;70(2):107-10. doi: 10.1136/bjo.70.2.107.

DOI:10.1136/bjo.70.2.107
PMID:3947604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1040930/
Abstract

A 31-year-old woman was diagnosed as having a malignant melanoma of the choroid in the right eye. Twenty months later her 7-year-old son was diagnosed as having retinoblastoma in the right eye. Both diagnoses were confirmed histopathologically after enucleation. A chromosomal study revealed normal karyotypes in the son. The family history was positive for cancer of the stomach. The implications of this rare association are discussed.

摘要

一名31岁女性被诊断为右眼脉络膜恶性黑色素瘤。20个月后,她7岁的儿子被诊断为右眼视网膜母细胞瘤。摘除眼球后经组织病理学检查确诊。染色体研究显示儿子的核型正常。家族史中胃癌呈阳性。本文讨论了这种罕见关联的意义。

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1
Malignant melanoma of the choroid in a mother and retinoblastoma in her son.一位母亲患脉络膜恶性黑色素瘤,其儿子患视网膜母细胞瘤。
Br J Ophthalmol. 1986 Feb;70(2):107-10. doi: 10.1136/bjo.70.2.107.
2
Retinoblastoma, melanoma and the atypical mole syndrome.视网膜母细胞瘤、黑色素瘤与非典型痣综合征。
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Choroidal malignant melanoma in siblings.兄弟姐妹中的脉络膜恶性黑色素瘤。
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Malignant melanoma of the choroid in a husband and wife.一对夫妻均患脉络膜恶性黑色素瘤。
Br J Ophthalmol. 1984 Sep;68(9):623-5. doi: 10.1136/bjo.68.9.623.
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Spontaneous regression of unilateral retinoblastoma in a father of three sons with bilateral retinoblastoma.
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Concurrent choroidal melanoma in son and father.父子同时患脉络膜黑色素瘤。
Am J Ophthalmol. 2000 Nov;130(5):679-80. doi: 10.1016/s0002-9394(00)00612-7.
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[Malignant melanoma after bilateral retinoblastoma].[双侧视网膜母细胞瘤后发生恶性黑色素瘤]
Presse Med. 1993 May 22;22(18):878.
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Bilateral spontaneous regression of retinoblastoma.视网膜母细胞瘤双侧自发消退
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Optic nerve changes in chorioidal malignant melanoma.脉络膜恶性黑色素瘤中的视神经改变
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Parents with unilateral retinoblastoma: their affected children.
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引用本文的文献

1
Hereditary melanoma and the search for the melanoma gene.
World J Surg. 1992 Mar-Apr;16(2):246-50. doi: 10.1007/BF02071528.

本文引用的文献

1
Familial retinoblastoma and chromosome 13 deletion transmitted via an insertional translocation.家族性视网膜母细胞瘤与通过插入易位传递的13号染色体缺失
Science. 1981 Sep 25;213(4515):1501-3. doi: 10.1126/science.7280668.
2
Association of retinoblastoma and acute lymphoblastic leukemia in a family.一个家族中视网膜母细胞瘤与急性淋巴细胞白血病的关联。
Am J Pediatr Hematol Oncol. 1982 Spring;4(1):37-9.
3
Cancer mortality in relatives of retinoblastoma patients.视网膜母细胞瘤患者亲属中的癌症死亡率。
J Natl Cancer Inst. 1984 Aug;73(2):303-11. doi: 10.1093/jnci/73.2.303.
4
Malignant melanoma of the choroid in a husband and wife.一对夫妻均患脉络膜恶性黑色素瘤。
Br J Ophthalmol. 1984 Sep;68(9):623-5. doi: 10.1136/bjo.68.9.623.
5
Heredity and intraocular malignant melanoma. Study of two families and review of forty-five cases.遗传与眼内恶性黑色素瘤。两个家族的研究及45例病例回顾。
Cancer. 1968 Jan;21(1):119-25. doi: 10.1002/1097-0142(196801)21:1<119::aid-cncr2820210118>3.0.co;2-w.
6
Heredity and cancer in man.人类的遗传与癌症。
Prog Med Genet. 1973;9:113-58.
7
Incidence of cancer in relatives of children with retinoblastoma.视网膜母细胞瘤患儿亲属患癌率
Br Med J. 1978 Jan 14;1(6105):83-4. doi: 10.1136/bmj.1.6105.83.
8
Genetics of retinoblastoma.视网膜母细胞瘤的遗传学
Hum Genet. 1979 Nov 1;52(1):1-54. doi: 10.1007/BF00284597.