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Wnt/GSK-3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon.

作者信息

Almozyan Sheema, Babaei-Jadidi Roya, Aljohani Abrar, Youssefi Sepideh, Dalleywater William, Kadam Prerna, Spencer-Dene Bradley, Rakha Emad, Ilyas Mohammad, Shams Nateri Abdolrahman

机构信息

Cancer Genetics & Stem Cell Group, BioDiscovery Institute, School of Medicine, University of Nottingham, Nottingham, Nottinghamshire, UK.

Department of Cell Therapy and Immunobiology, Research & Innovation Centre, King Faisal Specialist Hospital & Research Centre, RUH, Riyadh, Saudi Arabia.

出版信息

Cancer Commun (Lond). 2025 Jan;45(1):9-14. doi: 10.1002/cac2.12625. Epub 2024 Oct 30.

DOI:10.1002/cac2.12625
PMID:39476194
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11758259/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35a/11758259/4d965906de72/CAC2-45-9-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35a/11758259/4d965906de72/CAC2-45-9-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35a/11758259/4d965906de72/CAC2-45-9-g001.jpg

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本文引用的文献

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Clone wars: From molecules to cell competition in intestinal stem cell homeostasis and disease.克隆战争:从分子到细胞竞争在肠道干细胞稳态和疾病中的作用。
Exp Mol Med. 2022 Sep;54(9):1367-1378. doi: 10.1038/s12276-022-00854-5. Epub 2022 Sep 18.
2
Off-the-shelf proximity biotinylation for interaction proteomics.现货亲和素标记法用于相互作用蛋白质组学。
Nat Commun. 2021 Aug 18;12(1):5015. doi: 10.1038/s41467-021-25338-4.
3
FLYWCH1, a Multi-Functional Zinc Finger Protein Contributes to the DNA Repair Pathway.FLYWCH1,一种多功能锌指蛋白,有助于 DNA 修复途径。
Cells. 2021 Apr 13;10(4):889. doi: 10.3390/cells10040889.
4
Chromatin Dynamics in Intestinal Epithelial Homeostasis: A Paradigm of Cell Fate Determination versus Cell Plasticity.肠道上皮细胞稳态中的染色质动力学:细胞命运决定与细胞可塑性的范例。
Stem Cell Rev Rep. 2020 Dec;16(6):1062-1080. doi: 10.1007/s12015-020-10055-0. Epub 2020 Oct 13.
5
Cycling Stem Cells Are Radioresistant and Regenerate the Intestine.成体干细胞具有辐射抗性并能再生肠道。
Cell Rep. 2020 Jul 28;32(4):107952. doi: 10.1016/j.celrep.2020.107952.
6
FH535 inhibits proliferation and migration of colorectal cancer cells by regulating CyclinA2 and Claudin1 gene expression.FH535 通过调控细胞周期蛋白 A2 和闭合蛋白 1 基因的表达抑制结直肠癌细胞的增殖和迁移。
Gene. 2019 Mar 30;690:48-56. doi: 10.1016/j.gene.2018.12.008. Epub 2018 Dec 12.
7
FLYWCH1, a Novel Suppressor of Nuclear β-Catenin, Regulates Migration and Morphology in Colorectal Cancer.FLYWCH1,一种核 β-连环蛋白的新型抑制物,调节结直肠癌的迁移和形态。
Mol Cancer Res. 2018 Dec;16(12):1977-1990. doi: 10.1158/1541-7786.MCR-18-0262. Epub 2018 Aug 10.
8
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.DNA 修复网络分析揭示 Shieldin 作为 NHEJ 和 PARP 抑制剂敏感性的关键调节剂。
Cell. 2018 May 3;173(4):972-988.e23. doi: 10.1016/j.cell.2018.03.050. Epub 2018 Apr 12.
9
High-throughput discovery of novel developmental phenotypes.新型发育表型的高通量发现
Nature. 2016 Sep 22;537(7621):508-514. doi: 10.1038/nature19356. Epub 2016 Sep 14.
10
LIG4 mediates Wnt signalling-induced radioresistance.LIG4介导Wnt信号通路诱导的放射抗性。
Nat Commun. 2016 Mar 24;7:10994. doi: 10.1038/ncomms10994.