School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Industrial Development Center of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Int Immunopharmacol. 2024 Dec 25;143(Pt 2):113476. doi: 10.1016/j.intimp.2024.113476. Epub 2024 Oct 30.
Microglia are innate immune cells that maintain homeostasis of the central nervous system (CNS) and affect various neurodegenerative diseases, especially multiple sclerosis (MS). MS is an autoimmune disease of the CNS characterized by persistent inflammation, diffuse axonal damage, and microglia activation. Recent studies have shown that microglia are extremely related to the pathological state of MS and play an important role in the development of MS. This article reviews the multiple roles of microglia in the progression of MS, including the regulatory role of microglia in inflammation, remyelination, oxidative stress, the influence of phagocytosis and antigen-presenting capacity of microglia, and the recent progress by using microglia as a target for MS therapy. Microglia modulation may be a potential way for better MS therapy.
小胶质细胞是中枢神经系统（CNS）固有免疫细胞，可维持其内环境稳态，并影响多种神经退行性疾病，尤其是多发性硬化症（MS）。MS 是一种中枢神经系统自身免疫性疾病，其特征为持续炎症、弥漫性轴索损伤和小胶质细胞激活。最近的研究表明，小胶质细胞与 MS 的病理状态密切相关，在 MS 的发生发展中发挥重要作用。本文综述了小胶质细胞在 MS 进展中的多种作用，包括小胶质细胞在炎症、髓鞘再生、氧化应激中的调控作用，小胶质细胞吞噬和抗原呈递能力的影响，以及最近以小胶质细胞为靶点治疗 MS 的研究进展。小胶质细胞的调节可能是 MS 更好治疗的一种潜在方法。
