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编辑评论:“ACM诊断的三个步骤——有那么容易吗?”

Editorial commentary: "Three steps to ACM diagnosis - is it that easy?".

作者信息

Bhardwaj Priya, Jacobsen Stine B, Tfelt-Hansen Jacob

机构信息

Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

出版信息

Trends Cardiovasc Med. 2025 Feb;35(2):114-115. doi: 10.1016/j.tcm.2024.10.001. Epub 2024 Oct 29.

Abstract

Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease which predisposes to ventricular arrhythmias and sudden cardiac death. Since the introduction of the first diagnostic criteria in 1994, which focused exclusively on right ventricular involvement, diagnostic guidelines have evolved significantly over the past 30 years to encompass the full complexity of the ACM phenotype. In this issue of Trends in Cardiovascular Medicine, Graziano and colleagues review the advancements in ACM diagnostics which emphasizes a comprehensive evaluation of morpho-functional, structural, electrical, and genetic characteristics. The review outlines a three-step clinical approach for diagnosing ACM that involves assessing left and/or right ventricular involvement, identifying the specific ACM subtype, and determining its underlying etiology. This highlights the importance of interdisciplinary teamwork when approaching the complexities of diagnosing ACM and managing the family at risk.

摘要

致心律失常性心肌病(ACM)是一种遗传性心脏病,易引发室性心律失常和心源性猝死。自1994年首次出台仅关注右心室受累情况的诊断标准以来,在过去30年里,诊断指南已大幅演变,以涵盖ACM表型的全部复杂性。在本期《心血管医学趋势》中,格拉齐亚诺及其同事回顾了ACM诊断方面的进展,该进展强调对形态功能、结构、电学和遗传特征进行全面评估。这篇综述概述了诊断ACM的三步临床方法,包括评估左心室和/或右心室受累情况、确定特定的ACM亚型以及确定其潜在病因。这凸显了在应对诊断ACM的复杂性和管理高危家庭时跨学科团队合作的重要性。

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