Lavrent'ev V V, Konstantinova N A, Tumanova I A
Biull Eksp Biol Med. 1986 Feb;101(2):183-5.
The comparison of complement-fixing capacity of simulated immune complexes formed by normal IgG and IgG, isolated from serum of patients with multiple myeloma, has been performed. In both cases a non-linear dependence of complement-fixing capacity on the complex molecular mass was demonstrated, it being higher for myeloma proteins. Complement supplementation to high molecular complexes leads to their collapse, with normal immune complexes destroyed at lower molecular masses. Heat-aggregation of myeloma immunoglobulins leads to the formation of simulated immune complexes of lower molecular mass compared to normal proteins.
已对由正常IgG和从多发性骨髓瘤患者血清中分离出的IgG形成的模拟免疫复合物的补体结合能力进行了比较。在这两种情况下，均证实补体结合能力与复合物分子量呈非线性关系，骨髓瘤蛋白的补体结合能力更高。向高分子量复合物中补充补体导致其解体，正常免疫复合物在较低分子量时被破坏。与正常蛋白质相比，骨髓瘤免疫球蛋白的热聚集导致形成分子量较低的模拟免疫复合物。
