Surgery With or Without Radiotherapy Versus Radiotherapy Alone for Malignant Spinal Cord Compression : An Updated Meta-analysis.

STUDY DESIGN

A systematic review and meta-analysis.

OBJECTIVE

To conduct a meta-analysis of studies that compared surgery with or without radiotherapy to radiotherapy alone for patients with malignant spinal cord compression, and a subgroup analysis of patients stratified by hematologic and solid malignancies.

SUMMARY OF BACKGROUND DATA

Two previous meta-analyses showed that surgery with or without radiotherapy was better than radiotherapy alone in patients with malignant spinal cord compression. Nevertheless, there was no stratification by tumor type, leading to uncertainty regarding the best approach for patients with hematologic malignancies.

MATERIALS AND METHODS

We searched PubMed, Scopus, and Web of Science, for studies comparing surgery with or without radiotherapy to radiotherapy alone in patients with malignant spinal cord compression. The primary outcomes were improvement in ambulatory status and survival at 12 months. For neurological outcomes, we included studies involving both locally advanced primary malignancies of the spine and metastatic tumors. We restricted our analysis to studies on metastases for survival outcomes.

RESULTS

We included 2536 patients from 18 studies. Surgery was performed in 890 (35%) patients. The pooled analysis of all studies revealed that improvement in ambulatory status [odds ratio (OR): 2.65; 95% CI: 1.60-4.39] and survival at 12 months (OR: 1.66; 95% CI: 1.10-2.52) were significantly higher in patients who underwent surgery with or without radiotherapy. Improvement in ambulatory status (OR: 1.92; 95% CI: 1.19-3.09) and survival at 12 months (OR: 4.24; 95% CI: 2.35-7.66) were significantly higher in patients with hematologic malignancies in the surgical arm. The primary outcomes were not significantly different between patients with solid malignancies.

CONCLUSION

Surgical intervention demonstrates superior neurological outcomes and increased survival compared with radiotherapy alone. Subgroup analysis revealed that patients with hematologic malignancies in the surgery group experienced superior primary outcomes; however, the high risk of bias of the included studies precludes definitive changes in standard care based on this data. These findings underscore the need for further research regarding the efficacy of surgical versus radiotherapeutic approaches for specific tumor types.

LEVEL OF EVIDENCE

Level II.