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SARS-CoV-2 心血管症状的急性后期后遗症与影响心肌细胞功能的微量细胞因子有关。

Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function.

机构信息

School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.

Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia.

出版信息

Nat Microbiol. 2024 Dec;9(12):3135-3147. doi: 10.1038/s41564-024-01838-z. Epub 2024 Oct 30.

DOI:10.1038/s41564-024-01838-z
PMID:39478108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11602718/
Abstract

An estimated 65 million people globally suffer from post-acute sequelae of COVID-19 (PASC), with many experiencing cardiovascular symptoms (PASC-CVS) like chest pain and heart palpitations. This study examines the role of chronic inflammation in PASC-CVS, particularly in individuals with symptoms persisting over a year after infection. Blood samples from three groups-recovered individuals, those with prolonged PASC-CVS and SARS-CoV-2-negative individuals-revealed that those with PASC-CVS had a blood signature linked to inflammation. Trace-level pro-inflammatory cytokines were detected in the plasma from donors with PASC-CVS 18 months post infection using nanotechnology. Importantly, these trace-level cytokines affected the function of primary human cardiomyocytes. Plasma proteomics also demonstrated higher levels of complement and coagulation proteins in the plasma from patients with PASC-CVS. This study highlights chronic inflammation's role in the symptoms of PASC-CVS.

摘要

全球估计有 6500 万人患有 COVID-19 的急性后期后遗症（PASC），其中许多人经历心血管症状（PASC-CVS），如胸痛和心悸。本研究探讨了慢性炎症在 PASC-CVS 中的作用，特别是在感染后持续一年以上有症状的个体中。从三组人群的血液样本中发现，已康复者、PASC-CVS 持续时间较长者和 SARS-CoV-2 阴性者，PASC-CVS 患者的血液特征与炎症有关。使用纳米技术，在感染后 18 个月，从 PASC-CVS 供体的血浆中检测到微量水平的促炎细胞因子。重要的是，这些微量水平的细胞因子影响了原代人心肌细胞的功能。血浆蛋白质组学还表明，PASC-CVS 患者的血浆中补体和凝血蛋白水平更高。本研究强调了慢性炎症在 PASC-CVS 症状中的作用。

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引用本文的文献

[1]
Persistent Immune Dysregulation during Post-Acute Sequelae of COVID-19 is Manifested in Antibodies Targeting Envelope and Nucleocapsid Proteins.

bioRxiv. 2025-8-19

[2]
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[3]
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[4]
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[5]
Detrimental Effects of Anti-Nucleocapsid Antibodies in SARS-CoV-2 Infection, Reinfection, and the Post-Acute Sequelae of COVID-19.

Pathogens. 2024-12-15

[6]
Nanotech unveils cytokine traces in post-COVID cardiovascular complications.

Nat Immunol. 2024-12

本文引用的文献

[1]
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.

Nat Immunol. 2024-4

[2]
Spontaneous, persistent, T cell-dependent IFN-γ release in patients who progress to Long Covid.

Sci Adv. 2024-2-23

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Complement dysregulation is a prevalent and therapeutically amenable feature of long COVID.

Med. 2024-3-8

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Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm.

Dev Cell. 2024-3-25

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Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2.

Nat Immunol. 2024-2

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Proteomics and Metabolomics Reveal that an Abundant α-Glucosidase Drives Sorghum Fermentability for Beer Brewing.

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