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母亲在分娩期给药后脐带血中庆大霉素的浓度。

Umbilical cord blood gentamicin concentrations following maternally-administered intrapartum exposures.

作者信息

Coggins Sarah A, Wade Kelly C, Watt Kevin M, Downes Kevin J, Puopolo Karen M

机构信息

Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA.

出版信息

Pediatr Res. 2024 Oct 30. doi: 10.1038/s41390-024-03698-z.

DOI:10.1038/s41390-024-03698-z
PMID:39478198
Abstract

We identified cord blood gentamicin concentrations that were higher than anticipated, and above clinical targets for immediate gentamicin re-dosing after birth. Incorporation of gentamicin levels at birth may aid in optimizing postnatal gentamicin dosing among infants exposed to intrapartum gentamicin.

摘要

我们发现脐带血中庆大霉素浓度高于预期，且高于出生后立即重新注射庆大霉素的临床目标值。纳入出生时的庆大霉素水平可能有助于优化暴露于产时庆大霉素的婴儿出生后的庆大霉素给药方案。

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Pediatr Res. 2024 Oct 30. doi: 10.1038/s41390-024-03698-z.
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本文引用的文献

1
Early Antibiotic Exposure in Low-Risk Late Preterm and Term Infants.低危晚期早产儿和足月儿的早期抗生素暴露。
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The transplacental passage of commonly used intrapartum antibiotics and its impact on the newborn management: A narrative review.常用产时抗生素经胎盘转运及其对新生儿管理的影响：叙述性综述。
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一种定量、基于风险的新生儿早发性败血症管理方法。
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4
Population Pharmacokinetics and Dosing Considerations for Gentamicin in Newborns with Suspected or Proven Sepsis Caused by Gram-Negative Bacteria.疑似或确诊革兰氏阴性菌败血症新生儿庆大霉素的群体药代动力学及给药考量
Antimicrob Agents Chemother. 2016 Dec 27;61(1). doi: 10.1128/AAC.01304-16. Print 2017 Jan.
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Population pharmacokinetic study of gentamicin in a large cohort of premature and term neonates.庆大霉素在大量早产和足月新生儿队列中的群体药代动力学研究。
Br J Clin Pharmacol. 2014 Nov;78(5):1090-101. doi: 10.1111/bcp.12444.
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Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study.庆大霉素在早产儿和足月儿中的发育药代动力学：一项前瞻性研究的群体建模
Clin Pharmacokinet. 2009;48(4):253-63. doi: 10.2165/00003088-200948040-00003.
7
High compared with standard gentamicin dosing for chorioamnionitis: a comparison of maternal and fetal serum drug levels.与标准庆大霉素剂量治疗绒毛膜羊膜炎相比剂量较高：母体和胎儿血清药物水平的比较
Obstet Gynecol. 2005 Mar;105(3):473-9. doi: 10.1097/01.AOG.0000151106.87930.1a.
8
Ampicillin and gemtamicin in the treatment of fetal intrauterine infections.氨苄西林和庆大霉素用于治疗胎儿宫内感染。
J Perinat Med. 1980;8(1):13-8. doi: 10.1515/jpme.1980.8.1.13.