Hirai M, Nakayama R
Br J Surg. 1986 Jan;73(1):20-3. doi: 10.1002/bjs.1800730109.
The purpose of this study was to compare the haemodynamic effects of intra-arterial and intravenous prostaglandin E1 (PGE1) both injected and infused into ischaemic legs. Continuous intra-arterial infusion of PGE1 induced a significantly greater increase in skin temperature and blood flow than did intravenous drip infusion. Furthermore, intra-arterial infusion caused no steal phenomenon in the toe as indicated by skin temperature. On the other hand, toe skin temperature decreased during intravenous drip in 33 per cent of the legs tested. Continuous intravenous infusion also produced a significantly greater increase in toe skin temperature than did brief intravenous drip. In three of ten ulcers healed by continuous intra-arterial infusion, no definitive effect was obtained from continuous intravenous infusion even when it was repeated up to three times before continuous intra-arterial infusion. Intra-arterial injection of PGE1 caused no significant increase in toe skin temperature.
本研究的目的是比较经动脉和经静脉注射及输注前列腺素E1（PGE1）对缺血肢体的血流动力学影响。持续经动脉输注PGE1比静脉滴注能显著提高皮肤温度和血流量。此外，经动脉输注未导致趾部出现皮温所示的窃血现象。另一方面，在33%的受试肢体中，静脉滴注期间趾部皮肤温度下降。持续静脉输注比短暂静脉滴注也能使趾部皮肤温度显著升高。在经持续动脉输注愈合的10处溃疡中，有3处即使在持续动脉输注前重复静脉输注多达3次，也未获得确切效果。动脉注射PGE1未使趾部皮肤温度显著升高。
