Sant Bakshsingh Vibhootee, Sequeira Ruford
Internal Medicine, Royal Gwent Hospital, Newport, GBR.
Cureus. 2024 Sep 30;16(9):e70500. doi: 10.7759/cureus.70500. eCollection 2024 Sep.
Dopamine dysregulation syndrome (DDS) is a rare but significant complication of Parkinson's disease (PD), affecting approximately 3-4% of patients on long-term dopamine replacement therapy (DRT). It is characterized by an addictive pattern of DRT use that exceeds the necessary dosages for managing motor symptoms. Patients may engage in self-medication, escalating their DRT doses beyond prescribed limits, and strongly resist attempts to reduce medication. This syndrome often leads to impulsive behaviors, severe dyskinesia, and notable disruptions in social and occupational functioning. DDS is associated with a range of neuropsychiatric symptoms, including punding behaviors, hallucinations, and delusions. The management of DDS presents significant challenges, requiring a delicate balance between adequate symptom control and preventing medication overuse. We present a case of a 68-year-old woman with DDS, highlighting her symptoms and the tailored management strategies we employed to address this challenging condition.
多巴胺调节障碍综合征（DDS）是帕金森病（PD）一种罕见但严重的并发症，影响约3%-4%接受长期多巴胺替代疗法（DRT）的患者。其特征是多巴胺替代疗法的使用呈现成瘾模式，超过了控制运动症状所需的剂量。患者可能会自行用药，将多巴胺替代疗法的剂量增加到超出规定限度，并强烈抵制减少用药的尝试。这种综合征常导致冲动行为、严重的运动障碍以及社会和职业功能的显著紊乱。多巴胺调节障碍综合征与一系列神经精神症状有关，包括刻板行为、幻觉和妄想。多巴胺调节障碍综合征的管理面临重大挑战，需要在充分控制症状和防止药物滥用之间取得微妙平衡。我们报告一例68岁患有多巴胺调节障碍综合征的女性病例，突出她的症状以及我们为应对这一具有挑战性的病症所采用的个性化管理策略。
