The role of gut microbiome in mediating the effect of inflammatory bowel disease on hypertension: a two-step, two-sample Mendelian randomization study.

OBJECTIVE

Investigating the causal connection that exists between inflammatory bowel disease (IBD) and hypertension (HT). To gain a deeper insight into the correlation among IBD, gut microbiota, and HT, we conducted a two-step, two-sample Mendelian randomization study.

METHODS

An investigation of genome-wide association study (GWAS) summary-level data was utilized to conduct a two-sample Mendelian randomization (MR) analysis of genetically predicted inflammatory bowel disease: (12,882cases, 21,770controls) on Systolic/Diastolic blood pressure ( = 2,564). Subsequently, two-step MR analyses revealed that the relationship between IBD and SBP was partly mediated by . The robustness of the findings was confirmed through several sensitivity assessments.

RESULTS

This MR study showed that increase in genetically predicted IBD was associated with higher risk of genetically predicted SBP (OR: 1.08, 95% CI: 1.01-1.16,  < 0.05) and DBP (OR: 1.09, 95% CI: 1.02-1.17,  < 0.05), respectively. Inverse variance weighted (IVW) MR analysis also showed that increase in genetically predicted IBD was associated with higher abundance (OR: 1.03, 95% CI: 1.01-1.04,  < 0.05), which subsequently associated with increased SBP risk (OR: 1.42, 95% CI: 1.06-1.9,  < 0.05). abundance in stool was responsible for mediating 11% of the genetically predicted IBD on SBP.

CONCLUSION

The research proposed a causal link between Inflammatory Bowel Disease (IBD) and Hypertension (HT), with a little percentage of the impact being influenced by in stool. Mitigating gut microbiome may decrease the heightened risk of hypertension in people with inflammatory bowel disease.