Politis M J
Brain Res. 1986 Feb 5;364(2):369-71. doi: 10.1016/0006-8993(86)90849-8.
The ability of a growth-promoting extract derived from bovine retina was assessed for its ability to support nerve fiber regeneration from proximal stumps of transected sciatic nerves. Proximal stumps of transected rat peripheral nerves were inserted into the single inlet end of a 6 mm long Y-shaped Silastic implant. One of the paired outlets was attached to an Elvax pellet containing the retina-derived growth extract, and the other outlet to a pellet containing an equivalent amount of tissue extract-free Hank's balanced salt solution. At 3 weeks postoperatively, the number of axons and blood vessels in the midportion of implant forks was assessed. The extent of axonal regeneration and blood vessel formation induced were similar to each other and dose-dependent. Results indicate preferential and dose-dependent growth of axons toward pellets containing the retina-derived growth-promoting extract.
评估了一种源自牛视网膜的促生长提取物支持横断坐骨神经近端残端神经纤维再生的能力。将横断的大鼠外周神经近端残端插入一个6毫米长的Y形硅橡胶植入物的单入口端。一对出口中的一个连接到含有视网膜衍生生长提取物的聚乙烯醋酸乙烯酯小球，另一个出口连接到含有等量无组织提取物的汉克平衡盐溶液的小球。术后3周，评估植入物分叉中部的轴突和血管数量。诱导的轴突再生和血管形成程度相互相似且呈剂量依赖性。结果表明轴突向含有视网膜衍生促生长提取物的小球优先且呈剂量依赖性生长。
