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豚鼠海马体体外过氧化氢损伤的电生理相关性

Electrophysiological correlates of peroxide damage in guinea pig hippocampus in vitro.

作者信息

Pellmar T

出版信息

Brain Res. 1986 Feb 5;364(2):377-81. doi: 10.1016/0006-8993(86)90851-6.

DOI:10.1016/0006-8993(86)90851-6
PMID:3947975
Abstract

To study the effects of active oxygen on neuronal electrophysiology, hippocampal brain slices were exposed to hydrogen peroxide plus ferrous sulfate which react to produce hydroxyl free radicals. Analysis of extracellularly recorded somatic and dendritic responses to orthodromic stimulation indicated a decrease in both synaptic efficacy and impairment of action potential generation.

摘要

为研究活性氧对神经元电生理学的影响，将海马脑片暴露于过氧化氢和硫酸亚铁中，二者反应产生羟基自由基。对细胞外记录的躯体和树突对顺向刺激的反应进行分析，结果表明突触效能降低且动作电位产生受损。

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Electrophysiological correlates of peroxide damage in guinea pig hippocampus in vitro.豚鼠海马体体外过氧化氢损伤的电生理相关性
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