School of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
College of Science, Civil Aviation University of China, Tianjin 300300, China.
ACS Sens. 2024 Nov 22;9(11):6185-6196. doi: 10.1021/acssensors.4c02032. Epub 2024 Oct 31.
Noninvasive glucose sensors are emergent intelligent sensors for analyzing glucose concentration in body fluids within invasion-free conditions. Conventional glucose sensors are often limited by a number of issues such as invasive and real-time detection, creating challenges in continuously characterizing biomarkers or subtle binding dynamics. In this study, we introduce an efficient lossy mode resonance (LMR) optical fiber sensor incorporating the molecularly imprinted polymers (MIPs) to amplify glucose molecules. A molecularly imprinted recognition platform is created on an LMR sensor surface through a convenient one-step electrochemical (EC) polymerization method, in which 3-Aminophenylboric acid and glucose serve as the functional monomer and template molecule, respectively. LMR resonance wavelength shift induced by the coupling of the optical lossy mode and the fiber core mode is employed as the parameter to characterize biomolecules. Due to its high sensitivity to surrounding environment changes, a limit of detection (LOD) of 4.62 × 10 μmol/L for glucose can be achieved by this optical fiber sensor. Additionally, the prepared EC-MIPs LMR sensor is capable of detecting glucose molecules in human saliva samples with high accuracy, endowing its potential for practical applications.
非侵入式葡萄糖传感器是一种新兴的智能传感器，可在非侵入式条件下分析体液中的葡萄糖浓度。传统的葡萄糖传感器通常受到一些问题的限制，例如侵入性和实时检测，这给连续分析生物标志物或细微的结合动力学带来了挑战。在这项研究中，我们引入了一种高效的有损耗模式共振（LMR）光纤传感器，该传感器结合了分子印迹聚合物（MIPs）来放大葡萄糖分子。通过方便的一步电化学（EC）聚合方法，在 LMR 传感器表面上创建了分子印迹识别平台，其中 3-氨基苯硼酸和葡萄糖分别作为功能单体和模板分子。由于光学损耗模式和光纤芯模式的耦合引起的 LMR 共振波长位移被用作表征生物分子的参数。由于其对周围环境变化的高灵敏度，这种光纤传感器可以实现对葡萄糖的检测限（LOD）为 4.62×10 μmol/L。此外，所制备的 EC-MIPs LMR 传感器能够以高精度检测人唾液样本中的葡萄糖分子，赋予其实际应用的潜力。
