Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
Department of Psychology, University of California, Los Angeles.
J Psychopathol Clin Sci. 2024 Nov;133(8):638-646. doi: 10.1037/abn0000946.
Internalizing psychopathology is associated with abnormalities in heart rate variability (HRV). Lower HRV that reflects reduced parasympathetic nervous system activity has been observed in depressive and anxiety disorders. Existing studies predominantly used categorical rather than dimensional approaches, the latter of which better addresses clinical comorbidity and heterogeneity. Moreover, there is little evidence on the role of HRV in longitudinal symptom trajectory in adolescents and young adults. The current study examined the association between HRV and internalizing symptom trajectory using a dimensional approach-the tri-level model of depression and anxiety. Adolescents and young adults (N = 362) were recruited in a 3-year longitudinal study, where they completed electrocardiogram recordings and self-report symptom questionnaires. Multilevel modeling was conducted with high-frequency power bands (HF power) of interbeat intervals at baseline as the predictor, and tri-level symptom factors over 3 years as the outcome. HF power significantly predicted the trajectory of the broad General Distress symptom factor, but not the intermediate Fears or Anhedonia-Apprehension symptom factors. Higher HF power was associated with a decline in General Distress over time. This association was held when neuroticism, other tri-level symptom factors, and demographic variables were covaried. That is, greater parasympathetic nervous system activity at baseline was significantly associated with a greater decline in the broad internalizing symptom factor, but not symptom factors that are more specific to depressive or anxiety disorders. Parasympathetic activity, therefore, may be a transdiagnostic biomarker for internalizing symptoms in adolescents and young adults. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
内心化精神病理学与心率变异性（HRV）异常有关。在抑郁和焦虑障碍中观察到 HRV 降低，反映了副交感神经系统活动减少。现有的研究主要使用分类方法，而后者更好地解决了临床共病和异质性问题。此外，关于 HRV 在青少年和年轻人纵向症状轨迹中的作用的证据很少。本研究使用抑郁和焦虑的三级模型这种维度方法来检查 HRV 与内心化症状轨迹之间的关系。在一项为期 3 年的纵向研究中招募了青少年和年轻人（N=362），他们完成了心电图记录和自我报告的症状问卷。使用基线时的心跳间隔高频功率带（HF 功率）作为预测因子，对 3 年来的三级症状因素进行了多层次建模。HF 功率显著预测了广泛的一般困扰症状因素的轨迹，但不能预测中间的恐惧或快感缺失-忧虑症状因素。较高的 HF 功率与一般困扰随时间的下降有关。当控制神经质、其他三级症状因素和人口统计学变量时，这种关联仍然存在。也就是说，基线时更大的副交感神经活动与广泛的内心化症状因素的更大下降显著相关，而与更特定于抑郁或焦虑障碍的症状因素无关。因此，副交感神经活动可能是青少年和年轻人内心化症状的一种跨诊断生物标志物。（PsycInfo 数据库记录（c）2024 APA，保留所有权利）。
