固体燃料使用与中国四川良性前列腺增生症下尿路症状的相关性：横断面研究。

The Association Between Solid Fuel Use and Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia in Sichuan, China: Cross-Sectional Study.

机构信息

Department of Urology, Institute of Urology, National Clinical Research Center for Geriatrics and Center of Biomedical Big Data, West China Hospital of Sichuan University, Chengdu, China.

Institute of Hospital Management of West China Hospital/West China School of Nursing, Sichuan University, Chengdu, China.

出版信息

JMIR Public Health Surveill. 2024 Oct 31;10:e53673. doi: 10.2196/53673.

DOI:10.2196/53673

PMID:39481119

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11542908/

Abstract

BACKGROUND

Benign prostatic hyperplasia (BPH) is a global age-related disease. It has been reported that over half of the Chinese male population aged 70 years or older are experiencing BPH. Solid fuel, which is the major source of household air pollution, has been reportedly associated with several adverse events, including sex hormone disorders. Due to the certain relationship between sex hormone levels and prostate disease, the relationship between solid fuel use and lower urinary tract symptoms (LUTSs) suggestive of BPH (LUTS/BPH) deserves further exploration.

OBJECTIVE

This study mainly aimed to investigate the association between solid fuel use and LUTS/BPH.

METHODS

The data used in this study were obtained from the West China Natural Population Cohort Study. Household energy sources were assessed using questionnaires. LUTS/BPH was evaluated based on participant self-reports. We performed propensity score matching (PSM) to reduce the influence of bias and unmeasured confounders. The odds ratio (OR) and 95% CI of LUTS/BPH for the solid fuel group compared with the clean fuel group were calculated. We also conducted stratified analyses based on BMI, metabolic syndrome, waist to hip ratio, drinking status, smoking status, and age.

RESULTS

A total of 5463 participants were included in this study, including 399 solid fuel users and 5064 clean fuel users. After PSM, the solid fuel group included 354 participants, while the clean fuel group included 701 participants. Solid fuel use was positively correlated with LUTS/BPH before and after PSM (OR 1.68, 95% CI 1.31-2.15 and OR 1.81, 95% CI 1.35-2.44, respectively). In stratified analyses, the OR of the nonsmoking group was higher than that of the smoking group (OR 2.56, 95% CI 1.56-4.20 and OR 1.47, 95% CI 0.99-2.18, respectively). Similarly, the OR of the nondrinking group was higher than that of the drinking group (OR 2.70, 95% CI 1.46-4.99 and OR 1.48, 95% CI 1.01-2.17, respectively).

CONCLUSIONS

A positive correlation between solid fuel use and LUTS/BPH was observed. The results suggest that improving fuel structure for household cooking and other household needs can possibly help reduce the risk of LUTS/BPH.

摘要

背景

良性前列腺增生（BPH）是一种全球性的与年龄相关的疾病。据报道，超过一半的 70 岁及以上的中国男性患有 BPH。固体燃料是家庭空气污染的主要来源，据报道与多种不良事件有关，包括性激素紊乱。由于性激素水平与前列腺疾病之间存在一定关系，因此固体燃料使用与下尿路症状（LUTS）提示的 BPH（LUTS/BPH）之间的关系值得进一步探讨。

目的

本研究主要旨在探讨固体燃料使用与 LUTS/BPH 的关系。

方法

本研究使用的数据来自华西自然人群队列研究。使用问卷评估家庭能源来源。根据参与者的自我报告评估 LUTS/BPH。我们进行倾向评分匹配（PSM）以减少偏差和未测量混杂因素的影响。与清洁燃料组相比，固体燃料组患 LUTS/BPH 的比值比（OR）和 95%置信区间（CI）。我们还根据 BMI、代谢综合征、腰臀比、饮酒状态、吸烟状态和年龄进行了分层分析。

结果

本研究共纳入 5463 名参与者，其中 399 名固体燃料使用者和 5064 名清洁燃料使用者。PSM 后，固体燃料组包括 354 名参与者，而清洁燃料组包括 701 名参与者。固体燃料的使用与 PSM 前后的 LUTS/BPH 呈正相关（OR 1.68，95%CI 1.31-2.15 和 OR 1.81，95%CI 1.35-2.44）。在分层分析中，非吸烟者的 OR 高于吸烟者（OR 2.56，95%CI 1.56-4.20 和 OR 1.47，95%CI 0.99-2.18）。同样，非饮酒者的 OR 高于饮酒者（OR 2.70，95%CI 1.46-4.99 和 OR 1.48，95%CI 1.01-2.17）。