Park Ma Eum, Kim Da Young, Seo Jun-Won, Yun Na Ra, Lee You Mi, Kim Choon Mee, Kim Dong-Min
School of Medicine, Chosun University, Dong-gu, Gwangju, South Korea.
Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea.
Am J Trop Med Hyg. 2024 Oct 29;112(1):161-166. doi: 10.4269/ajtmh.24-0019. Print 2025 Jan 8.
Hemorrhagic fever with renal syndrome (HFRS) is caused by hantaviruses. Data of 34 patients with HFRS hospitalized at Chosun University Hospital, South Korea, between 2010 and 2021 were retrospectively analyzed. Nested reverse transcription polymerase chain reaction (RT-nPCR) targeting the L segment of hantavirus and sequencing were used for diagnosis. Most cases occurred in men and during the months of October through December. Common symptoms were fever, chills, gastrointestinal symptoms, and myalgia. The common laboratory abnormalities were thrombocytopenia, proteinuria, and elevated levels of serum creatinine, aspartate transaminase, alanine transaminase, and lactate dehydrogenase. Approximately 91.2% of patients had the Hantaan virus with a new genotype cluster, whereas 8.8% had the Seoul virus. Seropositivity based on IgM titer >1:32 on admission was noted in 20.6%, and a 4-fold increase in IgG titer of 1:512 was observed in 11.8%. This study demonstrated that RT-nPCR targeting the L segment of hantaviruses is a more reliable diagnostic method compared to serological testing.
肾综合征出血热（HFRS）由汉坦病毒引起。对2010年至2021年期间在韩国朝鲜大学医院住院的34例肾综合征出血热患者的数据进行了回顾性分析。采用针对汉坦病毒L片段的巢式逆转录聚合酶链反应（RT-nPCR）和测序进行诊断。大多数病例发生在男性以及10月至12月期间。常见症状为发热、寒战、胃肠道症状和肌痛。常见的实验室异常为血小板减少、蛋白尿以及血清肌酐、天冬氨酸转氨酶、丙氨酸转氨酶和乳酸脱氢酶水平升高。约91.2%的患者感染了具有新基因型簇的汉滩病毒，而8.8%的患者感染了汉城病毒。入院时IgM滴度>1:32的血清阳性率为20.6%，IgG滴度从1:512升高4倍的比例为11.8%。本研究表明，与血清学检测相比，针对汉坦病毒L片段的RT-nPCR是一种更可靠的诊断方法。
