Bacci G, Jaffe N, Emiliani E, Van Horn J, Manfrini M, Picci P, Bertoni F, Gherlinzoni F, Campanacci M
Cancer. 1986 Apr 15;57(8):1468-72. doi: 10.1002/1097-0142(19860415)57:8<1468::aid-cncr2820570806>3.0.co;2-0.
The authors report on the results obtained in 30 consecutive cases of primary non-Hodgkin's lymphoma of bone (PNHLB) treated at the Istituto Ortopedico Rizzoli between 1972 and 1982. Four patients were treated with radiotherapy only and 26 were treated with radiotherapy plus adjuvant chemotherapy. At a median follow-up of 86 months (range, 30-160), among the 26 patients treated with chemotherapy also there were 3 relapses (2 had meningeal involvement and 1 had recurrence in another bone). Relapse (local recurrence plus multiple new localizations) was observed in one of the four patients treated with radiotherapy only. These results are compared with the results of 68 patients with Ewing's sarcoma who were treated during the same period with radiation therapy and adjuvant chemotherapy and reported in a previous study. In this group, the disease-free survival rate was only 32% (20/68) with a much higher incidence of local recurrence (31%). The necessity of making a clear distinction between PNHLB and Ewing's sarcoma is discussed.
作者报告了1972年至1982年间在里佐利骨科研究所治疗的30例连续性原发性骨非霍奇金淋巴瘤（PNHLB）患者的结果。4例患者仅接受放射治疗，26例患者接受放射治疗加辅助化疗。中位随访86个月（范围30 - 160个月），在接受化疗的26例患者中，也有3例复发（2例有脑膜受累，1例在另一处骨复发）。仅接受放射治疗的4例患者中有1例出现复发（局部复发加多个新发病灶）。这些结果与同期接受放射治疗和辅助化疗的68例尤因肉瘤患者的结果进行了比较，该结果已在先前的一项研究中报告。在该组中，无病生存率仅为32%（20/68），局部复发发生率更高（31%）。讨论了明确区分PNHLB和尤因肉瘤的必要性。
