用α干扰素治疗毛细胞白血病。

Treatment of hairy cell leukemia with alpha interferons.

作者信息

Quesada J R, Gutterman J U, Hersh E M

出版信息

Cancer. 1986 Apr 15;57(8 Suppl):1678-80. doi: 10.1002/1097-0142(19860415)57:8+<1678::aid-cncr2820571308>3.0.co;2-6.

DOI:10.1002/1097-0142(19860415)57:8+<1678::aid-cncr2820571308>3.0.co;2-6

Abstract

A review of clinical research with alpha interferons in the treatment of hairy cell leukemia is presented. The results of several studies have shown that alpha interferons effectively reduce leukemic infiltrates in the bone marrow and other organs, with attendant resolution of cytopenias. Alpha interferons have shown efficacy in the treatment of patients in all clinical stages of the disease, including those previously untreated, and may become the treatment choice for hairy cell leukemia. Hairy cell leukemia will also provide a useful human clinical model in which some of the fundamental mechanisms of interferon activity can be studied.

摘要

本文综述了α干扰素治疗毛细胞白血病的临床研究。多项研究结果表明，α干扰素可有效减少骨髓及其他器官中的白血病浸润，并随之缓解血细胞减少症。α干扰素对处于该疾病所有临床阶段的患者均显示出疗效，包括那些既往未接受过治疗的患者，并且可能成为毛细胞白血病的治疗选择。毛细胞白血病也将提供一个有用的人类临床模型，借此可对干扰素活性的一些基本机制进行研究。