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Intrinsic Regulatory Mechanisms Protect Human Skin Mast Cells from Excessive MRGPRX2 Activation: Paucity in LAD2 (Laboratory of Allergic Diseases 2) Cells Contributes to Hyperresponsiveness of the Mast Cell Line.

作者信息

Li Zhuoran, Schneikert Jean, Bal Gürkan, Jin Manqiu, Franke Kristin, Zuberbier Torsten, Babina Magda

机构信息

Institute of Allergology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany; Department of Dermatology, The Second Hospital of Tianjin Medical University, Tianjin, China.

Institute of Allergology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.

出版信息

J Invest Dermatol. 2025 May;145(5):1215-1219.e4. doi: 10.1016/j.jid.2024.10.593. Epub 2024 Oct 30.

DOI:10.1016/j.jid.2024.10.593
PMID:39481529
Abstract
摘要

相似文献

1
Intrinsic Regulatory Mechanisms Protect Human Skin Mast Cells from Excessive MRGPRX2 Activation: Paucity in LAD2 (Laboratory of Allergic Diseases 2) Cells Contributes to Hyperresponsiveness of the Mast Cell Line.内在调节机制保护人类皮肤肥大细胞免受MRGPRX2过度激活：LAD2（变应性疾病实验室2）细胞中缺乏相关机制导致肥大细胞系反应过度。
J Invest Dermatol. 2025 May;145(5):1215-1219.e4. doi: 10.1016/j.jid.2024.10.593. Epub 2024 Oct 30.
2
Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCγ-IP3R related Ca fluctuations.槲皮素通过 PLCγ-IP3R 相关的 Ca2+波动抑制 Mrgprx2 诱导的类过敏反应。
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Amphotericin B for injection triggers degranulation of human LAD2 mast cells by MRGPRX2 and pseudo-allergic reactions in mice via MRGPRB2 activation.注射用两性霉素B通过MRGPRX2触发人LAD2肥大细胞脱颗粒，并通过激活MRGPRB2在小鼠中引发类过敏反应。
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Activation of ryanodine-sensitive calcium store drives pseudo-allergic dermatitis Mas-related G protein-coupled receptor X2 in mast cells.兰尼碱敏感钙库的激活驱动肥大细胞中的假性过敏性皮炎 Mas 相关 G 蛋白偶联受体 X2。
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Cisatracurium induces mast cell activation and pseudo-allergic reactions via MRGPRX2.顺式阿曲库铵通过 MRGPRX2 诱导肥大细胞活化和类过敏反应。
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MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway.MRGPRX2 是人类皮肤肥大细胞的可待因受体：通过β-arrestin 脱敏，与 FcεRI 途径无关。
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Differential MRGPRX2-dependent activation of human mast cells by polymyxins and octapeptins.多黏菌素和八肽通过差异 MRGPRX2 依赖性激活人肥大细胞。
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MrgprX2 regulates mast cell degranulation through PI3K/AKT and PLCγ signaling in pseudo-allergic reactions.MrgprX2在假过敏反应中通过PI3K/AKT和PLCγ信号通路调节肥大细胞脱颗粒。
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引用本文的文献

1
Icatibant Acts as a Balanced Ligand of MRGPRX2 in Human Skin Mast Cells.艾替班特在人皮肤肥大细胞中作为MRGPRX2的平衡配体发挥作用。
Biomolecules. 2025 Aug 25;15(9):1224. doi: 10.3390/biom15091224.
2
The prevalence of genetic variants of the Mas-related G-protein-coupled receptor X2 in patients does not explain perioperative hypersensitivity reactions to neuromuscular blocking agents.患者中与Mas相关的G蛋白偶联受体X2基因变异的患病率并不能解释围手术期对神经肌肉阻滞剂的过敏反应。
Front Pharmacol. 2025 Sep 1;16:1655722. doi: 10.3389/fphar.2025.1655722. eCollection 2025.