Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Department of Neurosurgery, Air Force Medical University Tangdu Hospital, Xi'an, China.
Microbiome. 2024 Nov 1;12(1):225. doi: 10.1186/s40168-024-01939-1.
Depression and anxiety significantly impact the quality of life in individuals with Cushing's disease (CD), which originates from pituitary neuroendocrine tumors (PitNETs), yet our understanding of the underlying mechanisms is limited. There is substantial evidence linking gut microbes to depression, anxiety, and endocrinology.
The gut bacterial phenotype of patients with Cushing's disease was significantly different from that of the control group, and when the mice were treated with fecal bacteria from these patients, both anxiety- and depression-like behavior were significantly increased. However, this effect can be alleviated by supplementing with 2-(14, 15-epoxyeicosatrienoyl) glycerol (2-14,15-EG) which was found at reduced levels in the peripheral blood of mice treated with coprofecal bacteria from Cushing's disease. In this process, the effects of hormone levels and immune factors were not significant. In addition, in an animal model, corticosterone has been observed to affect behavioral changes in mice through gut microbiota composition, clarifying the cause-and-effect relationship between hormones, microbiota, and behavior. Finally, there was no significant difference in gut microbiome composition and its effects on mouse behavior in patients with Cushing's disease with different levels of depression and anxiety.
In summary, this research enhances our current understanding of how gut microbes in patients with Cushing's disease contribute to depression and anxiety, offering novel insights for clinical treatment approaches. Video Abstract.
库欣病（CD）起源于垂体神经内分泌肿瘤（PitNETs），抑郁和焦虑显著影响患者的生活质量，但我们对其潜在机制的了解有限。有大量证据表明肠道微生物与抑郁、焦虑和内分泌学有关。
库欣病患者的肠道细菌表型与对照组有显著差异，当用这些患者的粪便细菌处理小鼠时，焦虑和抑郁样行为明显增加。然而，这种影响可以通过补充 2-(14,15-环氧二十碳三烯酰基)甘油（2-14,15-EG）来缓解，在接受库欣病粪便细菌处理的小鼠的外周血中发现这种物质的水平降低。在这个过程中，激素水平和免疫因素的影响并不显著。此外，在动物模型中，皮质酮被观察到通过肠道微生物群组成影响小鼠的行为变化，阐明了激素、微生物群和行为之间的因果关系。最后，在抑郁和焦虑程度不同的库欣病患者中，肠道微生物组组成及其对小鼠行为的影响没有显著差异。
总之，这项研究增强了我们对库欣病患者肠道微生物如何导致抑郁和焦虑的现有理解，为临床治疗方法提供了新的见解。视频摘要。
