Comparison of three elements (In, Sn, and Sb) in the same period as catalysts in the ring-opening polymerization of l-lactide: from amorphous to semicrystalline polyesters.

The ring-opening polymerization (ROP) of l-lactide (l-LA) is the main method for synthesizing poly(l-lactide) (PLLA), in which choosing the catalyst is one of the most important parameters. In this work, we focused on the systematic study of catalysts based on p-block elements from period 5, such as indium(iii), tin(ii), tin(iv) and antimony(iii) acetates, which displayed contrasting performances influenced by the oxidation state of the metal center. Analysis of the obtained oligomers by different techniques, including nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC), polarized optical microscopy (POM) and matrix-assisted laser desorption ionization-time-of-flight (MALDI-TOF), revealed the selectivity of each catalyst toward the ROP of l-LA. Tin(ii) acetate showed the best performance, making it the best catalyst of this series for synthesizing PLLA. Indium(iii) and tin(ii) acetates induced an amorphous and semicrystalline polyester, respectively. The kinetic study evidenced the excellent performance of tin(ii) acetate in the ROP of l-LA. This catalyst reached high conversions in a quarter of the total reaction time, positioning it as the most catalytically active of the selected p-block acetate catalysts. Finally, the coordination-insertion mechanism by the catalyst in the initiation step was corroborated through the development of a mechanistic study applying the density functional theory (DFT).