Ono Morio, Okabe Toshitaka, Isomura Naoei, Ochiai Masahiko
Division of Cardiology, Showa University Northern Yokohama Hospital, Tsuzuki, Yokohama, Japan.
J Cardiol Cases. 2024 Jun 15;30(3):97-100. doi: 10.1016/j.jccase.2024.05.010. eCollection 2024 Sep.
We encountered a case of coronary angina refractory to multiple medications, including a calcium channel blocker, nitroglycerin, fasudil (a Rho kinase inhibitor), left stellate ganglion block, thoracic sympathetic ganglion blockade, steroids, and denopamine. During the course of treatment, ventricular tachycardia (VT) occurred due to ST-segment elevation, and an implantable cardioverter-defibrillator was implanted; however, the patient had recurrent VT. A 12‑lead electrocardiogram showed ST elevation localized to leads II, III, and a Vf, and stenting was performed in all main trunks of the right coronary artery. After stenting, the daily angina attacks stopped, VT disappeared, and the chronic phase was controlled with her existing drug therapy, although she had mild chest pain attacks. There is limited evidence regarding the treatment of refractory angina pectoris. In this case, a patient with coronary angina pectoris refractory to various therapies underwent stenting, and the potentially fatal arrhythmia disappeared.
Management of refractory coronary angina pectoris poses a challenge. Despite attempting conventional therapies, our initial efforts were met with unsuccessful outcomes. Finally, we succeeded in treating the patient with stenting. This case report underscores the challenge of managing refractory coronary angina and explores diverse therapeutic approaches, including conventional medications, sympathetic nerve interventions, and stent placement.
我们遇到了一例对多种药物难治的冠状动脉性心绞痛病例,这些药物包括钙通道阻滞剂、硝酸甘油、法舒地尔(一种Rho激酶抑制剂)、左侧星状神经节阻滞、胸交感神经节阻滞、类固醇和多巴胺丁胺。在治疗过程中,由于ST段抬高出现了室性心动过速(VT),并植入了植入式心脏复律除颤器;然而,患者仍反复出现室性心动过速。一份12导联心电图显示ST段抬高局限于II、III和aVF导联,遂对右冠状动脉的所有主要分支进行了支架置入术。支架置入术后,每日心绞痛发作停止,室性心动过速消失,尽管患者仍有轻度胸痛发作,但在慢性期通过现有的药物治疗得到了控制。关于难治性心绞痛的治疗证据有限。在本病例中,一名对各种治疗均难治的冠状动脉性心绞痛患者接受了支架置入术,潜在的致命性心律失常消失。
难治性冠状动脉性心绞痛的管理具有挑战性。尽管尝试了传统疗法,但我们最初的努力并未取得成功。最终,我们成功地通过支架置入术治疗了该患者。本病例报告强调了管理难治性冠状动脉性心绞痛的挑战,并探讨了包括传统药物、交感神经干预和支架置入在内的多种治疗方法。