Goñi-Balentziaga Olatz, Díez-Solinska Alina, Beitia-Oyarzabal Garikoitz, Muñoz-Culla Maider, Azkona Garikoitz, Vegas Oscar
Department of Clinical and Health Psychology, and Research Methods, School of Psychology, University of the Basque Country (UPV/EHU), 20018 Donostia-San Sebastian, Spain;
Department of Basic Psychological Processes and Their Development, University of the Basque Country (UPV/EHU), 20018 Donostia-San Sebastian, Spain;
NeuroSci. 2024 Jun 6;5(2):192-200. doi: 10.3390/neurosci5020014. eCollection 2024 Jun.
Evidence indicates that chronic social stress plays a significant role in the development of cancer and depression. Although their association is recognized, the precise physiological mechanism remains unknown. In our previous work, we observed that OF1 males subjected to chronic social defiance exhibited anhedonia, and those who developed tumors in the lung showed anxiety-associated behaviors. In this study, we observed that tumor-bearing OF1 mice presented higher levels of 3-HK, and this increase may be due to IDO. No differences in hippocampal catecholamine levels were observed. Our results suggest that a systemic tumor can induce molecular changes in the hippocampal kynurenine pathway that may impact behavior.
有证据表明，慢性社会压力在癌症和抑郁症的发展中起着重要作用。尽管它们之间的关联已得到认可，但其确切的生理机制仍然未知。在我们之前的研究中，我们观察到遭受慢性社会对抗的OF1雄性小鼠表现出快感缺失，而那些肺部出现肿瘤的小鼠表现出与焦虑相关的行为。在本研究中，我们观察到荷瘤OF1小鼠的3-羟基犬尿氨酸（3-HK）水平较高，这种升高可能归因于吲哚胺2,3-双加氧酶（IDO）。未观察到海马体中儿茶酚胺水平的差异。我们的结果表明，全身性肿瘤可诱导海马体犬尿氨酸途径中的分子变化，这可能会影响行为。
