Butt Afia Tariq, Ramzan Sobia, Shabbir Dania, Sajjad Amna, Shaikh Murk, Syed Maryam Iqbal, Qamar Mohammad Aadil
Aga Khan University Hospital, Karachi, Pakistan.
PNS SHIFA Hospital, Karachi, Pakistan.
Glob Pediatr Health. 2024 Oct 22;11:2333794X241291409. doi: 10.1177/2333794X241291409. eCollection 2024.
Antimicrobial resistance (AMR) poses a significant threat to global public health, with substantial mortality rates attributed to AMR-related infections. Pediatric populations face heightened vulnerability due to prevalent antimicrobial misuse. This study aimed at addressing the significant threat of antimicrobial resistance (AMR) and its associated mortality rates. . This retrospective cross-sectional multicentric study investigated antibiotic prescribing patterns in pediatric wards of 4 secondary care hospitals affiliated with Aga Khan University Hospital. The study utilized the WHO Access, Watch, and Reserve (AWaRe) classification framework. Data from 6934 encounters were analyzed. . Antibiotics were prescribed in 78.1% of encounters, with intravenous administration being predominant (98.6%). Ceftriaxone was the most prescribed antibiotic agent (45.8%), and third-generation cephalosporins constituted the most prevalent antibiotic class (54.4%). Pneumonia exhibited the highest prescription rate (99.9%), with Watch group antibiotics being predominantly prescribed (>80%) across hospitals. . These findings underscore the urgency for targeted interventions to optimize prescribing practices and mitigate resistance.
抗菌药物耐药性（AMR）对全球公共卫生构成重大威胁，与AMR相关感染导致的死亡率相当高。由于普遍存在抗菌药物滥用现象，儿科人群面临更高的脆弱性。本研究旨在应对抗菌药物耐药性（AMR）的重大威胁及其相关死亡率。这项回顾性横断面多中心研究调查了阿迦汗大学医院附属的4家二级护理医院儿科病房的抗生素处方模式。该研究采用了世界卫生组织的获取、观察和储备（AWaRe）分类框架。对6934次诊疗的数据进行了分析。78.1%的诊疗中开具了抗生素，其中静脉给药为主（98.6%）。头孢曲松是处方最多的抗生素（45.8%），第三代头孢菌素是最常见的抗生素类别（54.4%）。肺炎的处方率最高（99.9%），各医院主要开具观察类抗生素（>80%）。这些发现凸显了采取针对性干预措施以优化处方行为和减轻耐药性的紧迫性。
