帕金森病早期即出现背外侧前额叶皮质神经元活动受损。
Impairment of Neuronal Activity in the Dorsolateral Prefrontal Cortex Occurs Early in Parkinsonism.
作者信息
Hjelle Noah, Mohanty Biswaranjan, Hubbard Tanner, Johnson Matthew D, Wang Jing, Johnson Luke A, Vitek Jerrold L
机构信息
Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
出版信息
bioRxiv. 2024 Oct 22:2024.10.22.619684. doi: 10.1101/2024.10.22.619684.
BACKGROUND
Parkinson's disease (PD) is often characterized by altered rates and patterns of neuronal activity in the sensorimotor regions of the basal ganglia thalamocortical network. Little is known, however, regarding how neuronal activity in the executive control network of the brain changes in the parkinsonian condition.
OBJECTIVE
Investigate the impact of parkinsonism on neuronal activity in the dorsolateral prefrontal cortex (DLPFC), a key region in executive control, during a go/nogo reaching task.
METHODS
Using a within-subject design, single and multi-unit neuronal activity was recorded in the DLPFC of a nonhuman primate before and after the induction of mild parkinsonism using the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
RESULTS
Coincident with development of mild parkinsonian motor signs, there was a marked reduction in the percentage of DLPFC cells with significant task-related firing rate modulation during go and nogo conditions.
CONCLUSIONS
These results suggest that DLPFC dysfunction may occur early in parkinsonism and contribute to cognitive impairments and disrupted executive function often observed in PD patients.
背景
帕金森病（PD）通常表现为基底神经节丘脑皮质网络感觉运动区域神经元活动速率和模式的改变。然而，关于帕金森病状态下大脑执行控制网络中的神经元活动如何变化，人们知之甚少。
目的
研究帕金森病对去/不去伸手任务期间背外侧前额叶皮质（DLPFC，执行控制的关键区域）神经元活动的影响。
方法
采用受试者内设计，在使用神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导轻度帕金森病之前和之后，记录一只非人灵长类动物DLPFC中的单单元和多单元神经元活动。
结果
与轻度帕金森病运动体征的出现相一致，在去和不去条件下，DLPFC中具有显著任务相关放电率调制的细胞百分比显著降低。
结论
这些结果表明，DLPFC功能障碍可能在帕金森病早期就会出现，并导致PD患者中经常观察到的认知障碍和执行功能受损。
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