Duus B R, Hølmich P, Larsen C T, Wille-Jørgensen P, Bjerg-Nielsen A, Christensen S
Clin Pharmacol Ther. 1986 Mar;39(3):342-4. doi: 10.1038/clpt.1986.50.
The effects of dihydroergotamine (DHE) on the degree of mobilization and response to orthostatic stress after total hip arthroplasty were studied. In the mobilization study, 78 patients received DHE, 0.5 mg im, twice a day from the day of surgery until full mobilization was achieved. Eighty-four patients who received placebo served as controls. There was no significant difference in the time until the first day of mobilization or the degree of mobilization. In the orthostatic test condition, subgroups of 61 patients receiving placebo and 55 patients receiving DHE were subjected to orthostatic testing. There were no differences in cardiovascular response to bed rest or in orthostatic stress. We conclude that DHE does not stabilize the cardiovascular reaction to orthostatic stress, nor does it enhance mobilization in patients after total hip arthroplasty.
研究了双氢麦角胺（DHE）对全髋关节置换术后体位改变应激的活动度及反应程度的影响。在活动度研究中，78例患者接受DHE，剂量为0.5mg，肌肉注射，每日两次，从手术日起直至完全活动自如。84例接受安慰剂的患者作为对照。在达到首次活动的时间或活动度方面，两组无显著差异。在体位测试条件下，61例接受安慰剂的患者亚组和55例接受DHE的患者亚组接受了体位测试。在卧床休息或体位应激时的心血管反应方面，两组无差异。我们得出结论，DHE不能稳定对体位应激的心血管反应，也不能增强全髋关节置换术后患者的活动度。
