Ding Yang, Ke Jie, Zhang Wenbin, Li Bin, He Chuan
Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
Guangdong Wamo New Material Technology CO., LTD, Jiangmen, Guangdong 529020, China.
Chem Commun (Camb). 2024 Nov 19;60(93):13734-13737. doi: 10.1039/d4cc05360e.
A highly efficient rhodium-catalyzed asymmetric hydrosilylation of aldehydes, ketones, and α,β-unsaturated ketones with dihydrosilanes is developed, that allows the rapid assembly of a variety of Si-stereogenic alkoxysilanes and silyl enol ethers in good yields and enantioselectivities under mild conditions. The applicability of this methodology was demonstrated by a series of stereospecific transformations to construct diverse Si-stereogenic derivatives.
开发了一种高效的铑催化醛、酮和α,β-不饱和酮与二氢硅烷的不对称硅氢化反应，该反应能在温和条件下以良好的产率和对映选择性快速合成各种具有硅立体中心的烷氧基硅烷和烯醇硅醚。通过一系列立体专一性转化构建各种具有硅立体中心的衍生物，证明了该方法的适用性。
