Taurbekova Binura, Mukhtarova Kymbat, Salpynov Zhandos, Almazan Joseph, Atageldiyeva Kuralay, Sarria-Santamera Antonio
Department of Biomedical Sciences, Nazarbayev University, School of Medicine, Astana, Kazakhstan.
Department of Surgery, Nazarbayev University, School of Medicine, Astana, Kazakhstan.
Curr Med Chem. 2024 Oct 31. doi: 10.2174/0109298673328801241015165257.
Diabetic kidney disease is a devastating diabetic complication, affecting up to half of people suffering from diabetes. The global burden of diabetic kidney disease is steadily increasing worldwide along with the growing prevalence of type 2 diabetes. The epidemic rise of type 2 diabetes is primarily observed in Asia, including the East Asian regions. It is generally accepted that heredity is one of the main determinants in the pathogenesis of diabetic kidney disease. Since the advent of genome-wide association studies, numerous studies have been published to identify the genetic loci susceptible to diabetic kidney disease among diverse populations. Although genome-wide association studies exploring diabetic kidney disease susceptibility loci have focused primarily on populations of European descent, a number of novel genetic variants associated with diabetic kidney disease have also been successfully revealed among East Asians. A comprehensive analysis of the genetic architecture and pathophysiological pathways of diabetic kidney disease may allow the identification of new potential therapeutic targets. This review aimed to summarize genome-wide association studies examining genetic variants associated with diabetic kidney disease in the populations of East Asian ancestry with type 2 diabetes and presented our perspective on the future of this field.
糖尿病肾病是一种极具破坏性的糖尿病并发症，影响着多达一半的糖尿病患者。随着2型糖尿病患病率的不断上升，全球糖尿病肾病负担在世界范围内正稳步增加。2型糖尿病的流行增长主要出现在亚洲，包括东亚地区。人们普遍认为，遗传是糖尿病肾病发病机制的主要决定因素之一。自全基因组关联研究出现以来，已经发表了大量研究来确定不同人群中易患糖尿病肾病的基因位点。尽管探索糖尿病肾病易感位点的全基因组关联研究主要集中在欧洲血统人群，但在东亚人群中也成功发现了一些与糖尿病肾病相关的新基因变异。对糖尿病肾病的遗传结构和病理生理途径进行全面分析，可能有助于识别新的潜在治疗靶点。本综述旨在总结针对2型糖尿病东亚血统人群中与糖尿病肾病相关基因变异的全基因组关联研究，并阐述我们对该领域未来发展的看法。
