A calculation of percutaneous drug absorption--II. Computation results.

The numerical computation data of percutaneous drug absorption are reported in this article. When the concentration of a drug in the uppermost epidermis can be considered unchanged, more than 50, 75, 90, 95 and 99% of the amount saturated at quasi-steady-state are accumulated after the respective time intervals of 0.5, 1, 2, 3 and 4 times the lag-time. After the ointment removal, the drug flux from the skin becomes linear on a semilogarithmic scale and the elimination rate constant is not dependent on the initial condition.