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A calculation of percutaneous drug absorption--I. Theoretical.

作者信息

Kubota K, Ishizaki T

出版信息

Comput Biol Med. 1986;16(1):7-19. doi: 10.1016/0010-4825(86)90058-2.

DOI:10.1016/0010-4825(86)90058-2
PMID:3948495
Abstract

Several theoreticals for simulating percutaneous drug absorption with a computer aid are proposed. By using our theoreticals, the simulation can be made for the process not only during an ointment application but also after its removal. The flow rate of drug from vehicle to skin and that from skin to blood also be estimated. In addition, we defined an apparent length of diffusion, ld and showed how to assess ld. The effect of a change in regional blood flow on drug flux from the skin at the quasi-steady-state is discussed.

摘要

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引用本文的文献

1
A two-dimensional mathematical model of non-linear dual-sorption of percutaneous drug absorption.经皮药物吸收的非线性双吸附二维数学模型。
Biomed Eng Online. 2005 Jul 3;4:40. doi: 10.1186/1475-925X-4-40.
2
A two-dimensional mathematical model of percutaneous drug absorption.经皮药物吸收的二维数学模型。
Biomed Eng Online. 2004 Jun 17;3(1):18. doi: 10.1186/1475-925X-3-18.
3
A diffusion-diffusion model for percutaneous drug absorption.
J Pharmacokinet Biopharm. 1986 Aug;14(4):409-39. doi: 10.1007/BF01059200.