探索炎性细胞因子与川崎病之间的因果关系：孟德尔随机化研究
Exploring Causal Correlations Between Inflammatory Cytokines and Kawasaki Disease: A Mendelian Randomization.
作者信息
Pan Yan, Jiao Fuyong
机构信息
Department of Pediatrics, The First Affiliated Hospital of Yangtze University, Jingzhou, China.
Shaanxi Kawasaki Disease Diagnosis and Treatment Center, Children's Hospital, Shaanxi Provincial People's Hospital of Xian, Jiaotong Univeristy, China.
出版信息
Fetal Pediatr Pathol. 2025 Jan-Feb;44(1):1-13. doi: 10.1080/15513815.2024.2414175. Epub 2024 Nov 1.
BACKGROUND
The role of inflammatory cytokines in Kawasaki disease (KD) pathogenesis is known, but causal relationships are unclear. This study investigates these connections using Mendelian randomization (MR).
METHODS
Genetic variations associated with KD were obtained from a GWAS including 119 cases and 6071 controls of European ancestry. Genetic data on inflammatory cytokines were sourced from a GWAS of 8,293 healthy participants.
RESULTS
The study identified significant associations between higher levels of macrophage colony stimulating factor (M-CSF), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and increased risk of KD. The odds ratios (OR) were 1.04 (95% CI: 1.01-1.08, = 0.010) for M-CSF, 1.03 (95% CI: 1.01-1.05, = 0.026) for MCP-1, and 1.02 (95% CI: 1.01-1.04, = 0.027) for TRAIL.
CONCLUSION
This study suggests that M-CSF, MCP-1, and TRAIL are potentially involved in the etiology of KD.
背景
炎症细胞因子在川崎病（KD）发病机制中的作用已为人所知，但因果关系尚不清楚。本研究采用孟德尔随机化（MR）方法来探究这些联系。
方法
与KD相关的基因变异来自一项全基因组关联研究（GWAS），该研究纳入了119例欧洲血统的病例和6071例对照。炎症细胞因子的基因数据来源于一项对8293名健康参与者的GWAS。
结果
该研究发现，较高水平的巨噬细胞集落刺激因子（M-CSF）、单核细胞趋化蛋白-1（MCP-1）和肿瘤坏死因子相关凋亡诱导配体（TRAIL）与KD风险增加之间存在显著关联。M-CSF的比值比（OR）为1.04（95%置信区间：1.01-1.08，P = 0.010），MCP-1为1.03（95%置信区间：1.01-1.05，P = 0.026），TRAIL为1.02（95%置信区间：1.01-1.04，P = 0.027）。
结论
本研究表明，M-CSF、MCP-1和TRAIL可能参与了KD的病因学过程。
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