表面之下：染色体 DNA 突变之外的新抗原。

Beneath the Surface: Neoantigens beyond Chromosomal DNA Mutations.

机构信息

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

出版信息

Cancer Discov. 2024 Nov 1;14(11):2066-2070. doi: 10.1158/2159-8290.CD-24-0830.

DOI:10.1158/2159-8290.CD-24-0830

PMID:39485251

Abstract

The conventional wisdom is that the overwhelming majority of neoantigens arise from chromosomal DNA mutations; however, recent studies show that posttranscriptional and posttranslational events can also generate neoantigens. This commentary provides an overview of known and potential sources of nonchromosomal neoantigens, emerging technologies, and clinical trials that may move this field forward to redefine immunologically "hot/cold" tumors and develop next-generation immunotherapeutic approaches.

摘要

传统观点认为，绝大多数新抗原源自染色体 DNA 突变；然而，最近的研究表明，转录后和翻译后事件也能产生新抗原。本文述评概述了已知和潜在的非染色体新抗原来源、新兴技术以及可能推动该领域发展的临床试验，以重新定义免疫上“热/冷”肿瘤，并开发下一代免疫治疗方法。