Schwartz R A, Cohen-Addad N, Lambert M W, Lambert W C
Cutis. 1986 Jan;37(1):37-9.
We report an infant who had diffuse blue hyperpigmentation at birth, which rapidly progressed to gray, over the back, buttocks, and posterior aspect of the legs, and an associated congenital anomaly. The entire thickness of the dermis contained numerous very prominent melanocytic cells which, especially in the superficial dermis, were markedly dendritic, rather than merely fusiform. An epidermal melanocyte proliferation was also present. Histologically, the lesion thus differed markedly from a mongolian spot. We believe that diffuse hyperpigmentation in the neonate should call attention to the possibility of an associated neuroectodermal malformation.
我们报告了一名婴儿，其出生时背部、臀部及腿部后侧有弥漫性蓝色色素沉着，且迅速发展为灰色，并伴有先天性异常。真皮全层含有大量非常显著的黑素细胞，尤其是在真皮浅层，这些细胞呈明显的树枝状，而非仅仅是梭形。表皮也有黑素细胞增殖。因此，从组织学上看，该病变与蒙古斑明显不同。我们认为，新生儿的弥漫性色素沉着应引起对相关神经外胚层畸形可能性的关注。
