Department of Pediatric Surgery, Karolinska University Hospital, Stockholm, Sweden.
Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
Pediatr Surg Int. 2024 Nov 1;40(1):285. doi: 10.1007/s00383-024-05860-4.
The survival rate (SR) for neonates born with congenital diaphragmatic hernia (CDH) remains high. Our aim was to investigate the change in SR in children with CDH over the past decades.
The study was a nationwide, population-based prospective nested case-control study within a cohort of newborn children who was born in Sweden during the observational period from 1st January 1982 to 31st December 2015.
In the study period, 4654 (99.6%) control children and 684 children with CDH (70.4%, p < 0.001) were with a survival of 2 years of age. Any patients who were born with CDH had a overall 5.8 times higher chance for not surviving 2 years of age than children without CDH. The SR improved significantly in CDH in the past 3 decades. Significantly higher number of patients were prematurely born in the CDH group than in the controls (23.3 vs 6.1%, p < 0.001). The SR of premature and non-premature born CDH patients has increased significantly over the past 3 decades.
The SR of CDH patients were significantly increased in the past 3 decades. The 2-year survival remains 5.8 times higher than those who were not born with CDH. These changes were mainly attributed to the improved SR of premature and non-premature born CDH patients.
患有先天性膈疝（CDH）的新生儿的存活率（SR）仍然很高。我们的目的是研究过去几十年中 CDH 患儿的 SR 变化。
本研究是在瑞典新生儿队列中进行的一项全国性、基于人群的前瞻性嵌套病例对照研究，观察期为 1982 年 1 月 1 日至 2015 年 12 月 31 日。
在研究期间，684 例 CDH 患儿（70.4%）和 4654 例对照儿童（99.6%）存活至 2 岁。任何患有 CDH 的患儿在 2 岁时没有存活的机会是没有 CDH 的儿童的 5.8 倍。在过去的 30 年中，CDH 的 SR 显著提高。CDH 组早产儿的比例明显高于对照组（23.3%比 6.1%，p<0.001）。过去 30 年来，早产儿和非早产儿 CDH 患者的 SR 均显著增加。
过去 30 年来，CDH 患儿的 SR 显著提高。2 年生存率仍然比未患 CDH 的患儿高 5.8 倍。这些变化主要归因于早产儿和非早产儿 CDH 患者的 SR 改善。
