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揭示酒精诱导女性不孕分子机制的研究——一种合理的方法。

Investigation of Uncovering Molecular Mechanisms of Alcohol-Induced Female Infertility-A Rational Approach.

作者信息

Lubau Natasha Sura Anak, Chengebroyen Neevashini, Subramaniyan Vetriselvan

机构信息

Pharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Malaysia.

Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Jalan University, Bandar Sunway, 47500, Selangor Darul Ehsan, Malaysia.

出版信息

Reprod Sci. 2024 Dec;31(12):3660-3672. doi: 10.1007/s43032-024-01692-8. Epub 2024 Nov 1.

Abstract

This study aimed to investigate the molecular mechanisms by which chronic alcohol consumption impacts female infertility, highlighting significant societal implications. By conducting a comprehensive literature review, we examined existing evidence on the association between long-term alcohol use and female reproductive health. Relevant studies were identified through systematic searches of electronic databases and key journals. We synthesized information on the molecular pathways affected by alcohol consumption, with particular emphasis on oxidative stress, inflammation, and hormonal disruptions. Additionally, we reviewed efforts to address alcohol-related health issues, including public health interventions, regulatory measures, and educational initiatives. Our study found strong evidence linking chronic alcohol consumption to increased mortality rates and a range of preventable diseases globally. Alcohol's effects extend beyond physiological consequences to psychological, social, and economic burdens. Chronic alcohol consumption disrupts hormonal balance and reproductive function, contributing to female infertility. Future research should focus on quantifying mortality risks associated with alcohol consumption, understanding gender-specific patterns in alcohol-related health outcomes, and elucidating the molecular mechanisms underlying female infertility. Addressing these gaps will inform strategies to mitigate the burden of alcohol-induced health issues and promote overall well-being. Collaborative efforts among diverse stakeholders are essential for advancing research agendas and translating findings into effective interventions.

摘要

本研究旨在探究长期饮酒影响女性不孕的分子机制,强调其重大的社会影响。通过进行全面的文献综述,我们审视了关于长期饮酒与女性生殖健康之间关联的现有证据。通过对电子数据库和主要期刊进行系统检索,确定了相关研究。我们综合了有关饮酒所影响的分子途径的信息,特别关注氧化应激、炎症和激素紊乱。此外,我们还回顾了应对与酒精相关健康问题的举措,包括公共卫生干预、监管措施和教育倡议。我们的研究发现有力证据表明,全球范围内长期饮酒与死亡率上升以及一系列可预防疾病有关。酒精的影响不仅限于生理后果,还包括心理、社会和经济负担。长期饮酒会扰乱激素平衡和生殖功能,导致女性不孕。未来的研究应侧重于量化与饮酒相关的死亡风险,了解酒精相关健康结果中的性别特定模式,并阐明女性不孕背后的分子机制。填补这些空白将为减轻酒精所致健康问题的负担和促进整体福祉的策略提供依据。不同利益相关者之间的合作努力对于推进研究议程并将研究结果转化为有效干预措施至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14c1/11611948/3cdd2f911236/43032_2024_1692_Fig1_HTML.jpg

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