PI3K/AKT 信号通路的重要作用及其相关抑制剂在前列腺癌进展中的作用。
Important Roles of PI3K/AKT Signaling Pathway and Relevant Inhibitors in Prostate Cancer Progression.
机构信息
Department of Clinical Medicine, Jining Medical University, Jining, China.
Department of Pathology, Jining First People's Hospital, Jining, China.
出版信息
Cancer Med. 2024 Nov;13(21):e70354. doi: 10.1002/cam4.70354.
Prostate cancer (PCa) is an extremely common malignant tumor of the male genitourinary system, originating from the prostate gland epithelium. Male patients are prone to relapse after treatment, which seriously threatens their health. Phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, also known as Akt) plays an important role in the growth, invasion, and metastasis of PCa. This review aimed to present an overview of the mechanism of action of the PI3K/AKT signaling pathway in PCa and discuss the application prospects of inhibitors of this pathway in treating PCa, providing a theoretical basis and reference for its clinical treatment targets.
前列腺癌（PCa）是男性泌尿生殖系统中一种极其常见的恶性肿瘤，起源于前列腺腺上皮。男性患者在治疗后容易复发，严重威胁其健康。磷酸肌醇 3-激酶（PI3K）/蛋白激酶 B（PKB，也称为 Akt）在 PCa 的生长、侵袭和转移中发挥重要作用。本综述旨在概述 PI3K/AKT 信号通路在 PCa 中的作用机制，并讨论该通路抑制剂在治疗 PCa 中的应用前景，为其临床治疗靶点提供理论依据和参考。
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