Rajasekariah G R, Deb B N, Dhage K R, Bose S
Chemotherapy. 1986;32(1):75-82. doi: 10.1159/000238391.
Hamsters infected with laboratory-adapted preadult Necator americanus were dosed with 6 reference anthelmintics. Their efficacy was measured in terms of percentage cure of infected animals as well as percentage worm reduction following treatment. Mebendazole and pyrantel were equally effective in this system. Other anthelmintics, including anti-hookworm compound, bephenium hydroxynaphthoate, were less effective. The comparative results revealed that the N. americanus model is sensitive and reliable for identifying and characterizing new anti-parasite preparations.
用实验室适应的未成熟美洲板口线虫感染仓鼠，然后给它们服用6种参考驱虫药。通过感染动物的治愈率以及治疗后蠕虫减少的百分比来衡量药物疗效。在这个系统中，甲苯达唑和噻嘧啶同样有效。其他驱虫药，包括抗钩虫化合物羟萘酸苄酚宁，效果较差。比较结果表明，美洲板口线虫模型对于鉴定和表征新的抗寄生虫制剂是敏感且可靠的。
