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Vitamin D Supplementation, Long-Term PM Exposure, and Severe Asthma Exacerbations in Children with Low Vitamin D: A Analysis of a Double-Blind, Randomized, Placebo-controlled Trial (VDKA).维生素D补充、长期暴露于细颗粒物与低维生素D儿童的严重哮喘发作：一项双盲、随机、安慰剂对照试验（VDKA）的分析
Am J Respir Crit Care Med. 2025 Feb;211(2):266-268. doi: 10.1164/rccm.202407-1353RL.
2
Vitamin D for the management of asthma.维生素 D 治疗哮喘。
Cochrane Database Syst Rev. 2023 Feb 6;2(2):CD011511. doi: 10.1002/14651858.CD011511.pub3.
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Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial.维生素 D3 补充对维生素 D 水平低的哮喘儿童重度哮喘发作的影响：VDKA 随机临床试验。
JAMA. 2020 Aug 25;324(8):752-760. doi: 10.1001/jama.2020.12384.
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Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data.维生素 D 补充预防哮喘恶化：一项个体参与者数据的系统评价和荟萃分析。
Lancet Respir Med. 2017 Nov;5(11):881-890. doi: 10.1016/S2213-2600(17)30306-5. Epub 2017 Oct 3.
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Vitamin D Supplementation, Chronic Obstructive Lung Disease and Asthma Exacerbations, and Lung Function Decline.维生素D补充、慢性阻塞性肺疾病与哮喘急性加重以及肺功能下降
J Nutr. 2025 May;155(5):1417-1428. doi: 10.1016/j.tjnut.2025.02.003. Epub 2025 Feb 6.
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Vitamin D for the management of chronic obstructive pulmonary disease.维生素D用于慢性阻塞性肺疾病的管理
Cochrane Database Syst Rev. 2024 Sep 27;9(9):CD013284. doi: 10.1002/14651858.CD013284.pub2.
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Vitamin D supplementation for sickle cell disease.镰状细胞病的维生素D补充治疗
Cochrane Database Syst Rev. 2017 Jan 20;1(1):CD010858. doi: 10.1002/14651858.CD010858.pub2.
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A randomized comparison of intramuscular high-dose versus oral maintenance vitamin D to prevent severe exacerbations in deficient/insufficient asthmatic children.肌肉注射大剂量维生素D与口服维持剂量维生素D预防维生素D缺乏/不足哮喘儿童严重发作的随机对照研究
J Allergy Clin Immunol Glob. 2025 May 21;4(3):100497. doi: 10.1016/j.jacig.2025.100497. eCollection 2025 Aug.
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Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.茯苓多糖对常年性哮喘儿童哮喘控制及呼吸道感染频率的有益作用。
Sci Rep. 2025 Feb 28;15(1):7146. doi: 10.1038/s41598-025-91830-2.
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Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial.维生素 D 补充对妊娠期糖尿病患者糖代谢、血脂浓度、炎症和氧化应激的影响：一项双盲随机对照临床试验。
Am J Clin Nutr. 2013 Dec;98(6):1425-32. doi: 10.3945/ajcn.113.072785. Epub 2013 Oct 16.

引用本文的文献

1
Limitations in the Study of Vitamin D Supplementation and Severe Asthma Exacerbations.维生素D补充与严重哮喘发作研究的局限性。
Am J Respir Crit Care Med. 2025 Mar;211(3):530. doi: 10.1164/rccm.202411-2236LE.
2
Reply to Cheng and Wei: Limitations in the Study of Vitamin D Supplementation and Severe Asthma Exacerbations.对程和魏的回复：维生素D补充与严重哮喘发作研究的局限性
Am J Respir Crit Care Med. 2025 Mar;211(3):531-532. doi: 10.1164/rccm.202411-2311LE.

本文引用的文献

1
Long-Term Exposure to Particulate Matter <2.5 μm and Lung Function Change in Children with Asthma Receiving Inhaled Corticosteroids.长期暴露于直径<2.5微米的颗粒物与接受吸入性糖皮质激素治疗的哮喘儿童肺功能变化
Am J Respir Crit Care Med. 2023 Sep 1;208(5):622-624. doi: 10.1164/rccm.202303-0371LE.
2
Maternal vitamin D status modifies the effects of early life tobacco exposure on child lung function.母亲的维生素 D 状况会改变儿童早期吸烟暴露对肺功能的影响。
J Allergy Clin Immunol. 2023 Feb;151(2):556-564. doi: 10.1016/j.jaci.2022.10.030. Epub 2022 Nov 16.
3
Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial.维生素 D3 补充对维生素 D 水平低的哮喘儿童重度哮喘发作的影响：VDKA 随机临床试验。
JAMA. 2020 Aug 25;324(8):752-760. doi: 10.1001/jama.2020.12384.
4
Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter.维生素 D 对暴露于颗粒物的人支气管上皮细胞炎症和氧化应激反应的影响。
PLoS One. 2018 Aug 29;13(8):e0200040. doi: 10.1371/journal.pone.0200040. eCollection 2018.
5
Vitamin D supplementation attenuates asthma development following traffic-related particulate matter exposure.维生素 D 补充可减轻交通相关颗粒物暴露后哮喘的发展。
J Allergy Clin Immunol. 2019 Jan;143(1):386-394.e3. doi: 10.1016/j.jaci.2018.04.042. Epub 2018 Jun 21.
6
Vitamin D Counteracts an IL-23-Dependent IL-17AIFN-γ Response Driven by Urban Particulate Matter.维生素D可对抗由城市颗粒物驱动的依赖白细胞介素-23的白细胞介素-17A/干扰素-γ反应。
Am J Respir Cell Mol Biol. 2017 Sep;57(3):355-366. doi: 10.1165/rcmb.2016-0409OC.
7
Proximity to a major road, vitamin D insufficiency, and severe asthma exacerbations in Puerto Rican children.波多黎各儿童居住在主干道附近、维生素D缺乏与严重哮喘发作的关系
Am J Respir Crit Care Med. 2014 Nov 15;190(10):1190-3. doi: 10.1164/rccm.201408-1568LE.
8
Diesel exhaust particle induction of IL-17A contributes to severe asthma.柴油机废气颗粒诱导白细胞介素-17A 导致严重哮喘。
J Allergy Clin Immunol. 2013 Nov;132(5):1194-1204.e2. doi: 10.1016/j.jaci.2013.06.048. Epub 2013 Sep 20.
9
Outdoor exposure and vitamin D levels in urban children with asthma.城市哮喘儿童的户外暴露与维生素D水平
Nutr J. 2013 Jun 12;12:81. doi: 10.1186/1475-2891-12-81.
10
Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations.用于 3-95 岁年龄范围的肺量测定的多民族参考值：全球肺功能 2012 方程。
Eur Respir J. 2012 Dec;40(6):1324-43. doi: 10.1183/09031936.00080312. Epub 2012 Jun 27.

Vitamin D Supplementation, Long-Term PM Exposure, and Severe Asthma Exacerbations in Children with Low Vitamin D: A Analysis of a Double-Blind, Randomized, Placebo-controlled Trial (VDKA).

作者信息

Rosser Franziska J, Han Yueh-Ying, Forno Erick, Guilbert Theresa W, Bacharier Leonard B, Phipatanakul Wanda, Celedón Juan C

机构信息

Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania.

Division of Pulmonary Medicine, Department of Pediatrics, Riley Children's Hospital, University of Indiana, Indianapolis, Indiana.

出版信息

Am J Respir Crit Care Med. 2025 Feb;211(2):266-268. doi: 10.1164/rccm.202407-1353RL.

DOI:10.1164/rccm.202407-1353RL
PMID:39485865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11812543/
Abstract
摘要