State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, PR China; School of Food Science and Technology, Nanchang University, Nanchang 330047, PR China; Jiangxi Province Key Laboratory of Food Allergy, Nanchang University, Nanchang 330047, China.
Sino-German Joint Research Institute, Nanchang University, Nanchang 330047, PR China; Jiangxi Province Key Laboratory of Food Allergy, Nanchang University, Nanchang 330047, China.
Food Chem. 2025 Feb 1;464(Pt 3):141821. doi: 10.1016/j.foodchem.2024.141821. Epub 2024 Oct 29.
Although various studies have been conducted, the detailed mechanisms of food allergy remain a topic of ongoing debate. Recently, researchers have reported that extracellular adenosine triphosphate (eATP), a member of damage-associated molecular patterns secreted by stressed cells, plays a critical role in the progression of asthma and atopic dermatitis. These studies suggest that dysregulated eATP significantly influences various aspects of disease progression, from bodily sensitization to the emergence of clinical manifestations. Given the shared pathogenic mechanisms among asthma, atopic dermatitis, and food allergies, we hypothesize that eATP may also serve as a crucial regulator in the development of food allergies. To elucidate this hypothesis, we first summarize the evidence and limitations of food allergy theories, then discuss the roles of eATP in allergic diseases. We conclude with speculative insights into the potential influence of eATP on food allergy development, aiming to inspire further investigation into the molecular mechanisms of food allergies.
尽管已经进行了各种研究，但食物过敏的详细机制仍然是一个正在讨论的话题。最近，研究人员报告称，细胞外三磷酸腺苷（eATP）是应激细胞分泌的损伤相关分子模式的成员，在哮喘和特应性皮炎的进展中发挥着关键作用。这些研究表明，失调的 eATP 显著影响疾病进展的各个方面，从身体致敏到临床表现的出现。鉴于哮喘、特应性皮炎和食物过敏之间存在共同的发病机制，我们假设 eATP 也可能是食物过敏发展过程中的一个关键调节剂。为了阐明这一假设，我们首先总结了食物过敏理论的证据和局限性，然后讨论了 eATP 在过敏性疾病中的作用。最后，我们对 eATP 对食物过敏发展的潜在影响进行了推测性的探讨，旨在为食物过敏的分子机制研究提供启示。
