Weitman S D, Vodicnik M J, Lech J J
Dev Pharmacol Ther. 1986;9(1):23-31. doi: 10.1159/000457073.
The effect of pregnancy on the hepatic metabolism of parathion was examined. The in vitro rate of hepatic microsomal activation of parathion to paraoxon was significantly reduced in mice at 19 days of gestation when compared to nonpregnant controls. Total hepatic metabolism of parathion was determined during in situ perfusion of livers from pregnant and nonpregnant mice. Levels of parathion, paraoxon, and p-nitro-phenol in the perfusate after 45 min of perfusion did not differ significantly between livers from the pregnant and nonpregnant groups. These data indicate that total hepatic metabolism of these three compounds is not altered in pregnancy despite a decrease in specific activity for parathion activation.
研究了妊娠对硫磷肝脏代谢的影响。与未怀孕的对照组相比，妊娠19天的小鼠肝脏微粒体将硫磷激活为对氧磷的体外速率显著降低。在对怀孕和未怀孕小鼠的肝脏进行原位灌注期间，测定了硫磷的肝脏总代谢情况。灌注45分钟后，怀孕组和未怀孕组肝脏灌注液中硫磷、对氧磷和对硝基苯酚的水平没有显著差异。这些数据表明，尽管硫磷激活的比活性降低，但这三种化合物的肝脏总代谢在妊娠期间并未改变。
