找到合适的朋友：基质组成影响卵巢癌中 TLS 的形成。
Finding the right friends: Stromal composition influences TLS formation in ovarian cancer.
机构信息
Mass General Cancer Center, Krantz Family Center for Cancer Research, Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
出版信息
Cancer Cell. 2024 Nov 11;42(11):1811-1812. doi: 10.1016/j.ccell.2024.10.004. Epub 2024 Oct 31.
In this issue of Cancer Cell, MacFawn et al. reveal that tertiary lymphoid structures (TLSs) in high-grade serous ovarian cancer (HGSOC) vary significantly by anatomical site. They highlight a distinct stromal composition associated with TLS formation, with cancer-educated mesenchymal stem cells (CA-MSCs) inversely linked to TLS activity and patient prognosis.
在本期《癌细胞》中，MacFawn 等人揭示了高级别浆液性卵巢癌（HGSOC）中的三级淋巴结构（TLS）在解剖部位上存在显著差异。他们强调了与 TLS 形成相关的独特基质组成，与 TLS 活性和患者预后呈负相关的是癌源性间充质干细胞（CA-MSCs）。
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