Mass General Cancer Center, Krantz Family Center for Cancer Research, Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Cancer Cell. 2024 Nov 11;42(11):1811-1812. doi: 10.1016/j.ccell.2024.10.004. Epub 2024 Oct 31.
In this issue of Cancer Cell, MacFawn et al. reveal that tertiary lymphoid structures (TLSs) in high-grade serous ovarian cancer (HGSOC) vary significantly by anatomical site. They highlight a distinct stromal composition associated with TLS formation, with cancer-educated mesenchymal stem cells (CA-MSCs) inversely linked to TLS activity and patient prognosis.
在本期《癌细胞》中，MacFawn 等人揭示了高级别浆液性卵巢癌（HGSOC）中的三级淋巴结构（TLS）在解剖部位上存在显著差异。他们强调了与 TLS 形成相关的独特基质组成，与 TLS 活性和患者预后呈负相关的是癌源性间充质干细胞（CA-MSCs）。
