Zhang Ting, Zheng Jianfeng, Chen Mengjie, Li Dan, Sun Yuan, Liu Rui, Sun Tiedong
Center of Pharmaceutical Engineering and Technology, Harbin University of Commerce, Harbin 150076, PR China.
Center of Pharmaceutical Engineering and Technology, Harbin University of Commerce, Harbin 150076, PR China.
Int J Biol Macromol. 2024 Dec;282(Pt 3):137007. doi: 10.1016/j.ijbiomac.2024.137007. Epub 2024 Oct 30.
Zanthoxylum bungeanum Maxim (Z. bungeanum), commonly known as Sichuan pepper or Chinese prickly ash, is a deciduous shrub in the Rutaceae family, with a lengthy history of use as a food ingredient and traditional medicine in China. Z. bungeanum polysaccharides (ZBPs) represent one of the crucial bioactive components of Z. bungeanum, garnering global attention due to their potential medicinal value, culinary significance, and promising application prospects. The principal methods for extracting ZBPs are hot water extraction, ultrasound-assisted extraction, enzyme-assisted extraction and microbial fermentation extraction. However, the structural characteristics of ZBPs remain ambiguous, necessitating further exploration and elucidation of the structure-activity relationship using the advanced analytical techniques. In addition, ZBPs demonstrate diverse bioactivities, including antioxidant activity, neuroprotective effect, antibacterial activity, and the anti-fatigue effect, positioning them as promising candidates for various therapeutic and health-promoting applications. This review provides a comprehensive overview of the extraction, purification, structural characteristics, bioactivities, and potential applications of ZBPs, emphasizing the significant promise of ZBPs as valuable natural compounds with a range of bioactivities, supporting their further exploitation and application in various fields of industries and therapeutics.
花椒(Zanthoxylum bungeanum Maxim),俗称四川花椒或中国花椒,是芸香科的一种落叶灌木,在中国作为食品成分和传统药物有着悠久的使用历史。花椒多糖(ZBPs)是花椒的关键生物活性成分之一,因其潜在的药用价值、烹饪意义和广阔的应用前景而受到全球关注。提取ZBPs的主要方法有热水提取、超声辅助提取、酶辅助提取和微生物发酵提取。然而,ZBPs的结构特征仍不明确,需要使用先进的分析技术进一步探索和阐明其构效关系。此外,ZBPs具有多种生物活性,包括抗氧化活性、神经保护作用、抗菌活性和抗疲劳作用,使其成为各种治疗和促进健康应用的有前途的候选物。本文综述了ZBPs的提取、纯化、结构特征、生物活性和潜在应用,强调了ZBPs作为具有一系列生物活性的有价值天然化合物的巨大前景,支持其在工业和治疗的各个领域的进一步开发和应用。