First Affiliated Hospital of Kunming Medical University, Kunming, China.
Sci Rep. 2024 Nov 2;14(1):26375. doi: 10.1038/s41598-024-76972-z.
In recent years, worldwide fertility rates have continued to decrease. Humans are frequently exposed to a combination of environmental endocrine disruptors, which can cause male reproductive disorders. The study employed three distinct analytical models to examine the correlation between exposure to a combination of 25 chemicals and sex steroid hormone levels in adult males. This involved evaluating 12 chemicals and their metabolites from personal care and consumer products, as well as 13 metabolites linked to phthalates and plasticisers. The study analysed 25 chemicals and 3 measured sex steroid hormone outcomes, as well as two calculated hormonal outcomes (free androgen index, TT/E2 ratio) in 1262 adult men who participated in the National Health and Nutrition Examination Survey (NHANES) 2013-2016 in the United States. The study employed several statistical methods to estimate the relationships between single chemicals or chemical blends and sex hormones. These methods included linear regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine (BKMR) regression. The results of the linear regression analysis indicate that chemical exposure has a negative correlation with E2, TT, and FAI, and a positive correlation with SHBG and TT/E2. The mixture effect analyses using the WQS and BKMR models further confirmed that BP3, MECPP, and MECOP were the most highly weighted chemical mixtures. The analyses also suggested that there were differences in the effects of different concentrations of EDCs on sex steroid hormones. Exposure to environmental endocrine-disrupting chemicals (EDCs) has been found to have a negative correlation with estradiol and total testosterone, as well as FAI. Conversely, this exposure has been found to have a positive correlation with sex hormone binding globulin and the TT/E2 ratio. The study also revealed differences in the effects of different concentrations of EDCs.
近年来，全球生育率持续下降。人类经常接触到环境内分泌干扰物的组合，这可能导致男性生殖系统紊乱。该研究采用了三种不同的分析模型来研究男性成年人接触 25 种化学物质组合与性激素水平之间的相关性。研究评估了 12 种来自个人护理和消费产品的化学物质及其代谢物，以及与邻苯二甲酸酯和增塑剂有关的 13 种代谢物。该研究分析了 1262 名参加美国 2013-2016 年国家健康和营养调查（NHANES）的成年男性的 25 种化学物质和 3 种测量性激素结果，以及 2 种计算的激素结果（游离雄激素指数，TT/E2 比值）。研究采用了几种统计方法来估计单一化学物质或化学混合物与性激素之间的关系。这些方法包括线性回归、加权分位数总和（WQS）回归和贝叶斯核机器（BKMR）回归。线性回归分析的结果表明，化学物质暴露与 E2、TT 和 FAI 呈负相关，与 SHBG 和 TT/E2 呈正相关。使用 WQS 和 BKMR 模型进行的混合物效应分析进一步证实，BP3、MECPP 和 MECOP 是权重最高的化学混合物。分析还表明，不同浓度的 EDCs 对性激素的影响存在差异。接触环境内分泌干扰化学物质（EDCs）已被发现与雌二醇和总睾酮以及 FAI 呈负相关。相反，这种接触与性激素结合球蛋白和 TT/E2 比值呈正相关。研究还揭示了不同浓度的 EDCs 对其影响的差异。
