高胫骨截骨术联合富血小板血浆治疗膝骨关节炎的疗效和安全性：中国人群的系统评价和荟萃分析。
Efficacy and safety of high tibial osteotomy combined with platelet-rich plasma for treating knee osteoarthritis: a systematic review and meta-analysis of the Chinese population.
机构信息
Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, China.
Qionglai Hospital of Traditional Chinese Medicine, Chengdu, Sichuan, 611530, China.
出版信息
BMC Musculoskelet Disord. 2024 Nov 1;25(1):876. doi: 10.1186/s12891-024-08004-w.
OBJECTIVE
To systematically review the clinical efficacy and safety of high tibial osteotomy (HTO) combined with platelet-rich plasma (PRP) for treating knee osteoarthritis (KOA) and to provide evidence of the effectiveness of evidence-based medicine for treating this disease.
METHODS
Clinical studies on the use of HTO combined with PRP for the treatment of KOA before September 2024 were identified. The literature that met the inclusion criteria was strictly screened out, the literature information was extracted, and the data were input into RevMan5.4 for analysis.
RESULTS
Ten studies (12 controls) with 625 patients were included. Overall, the visual analog scale (VAS) score (mean difference (MD) = -0.53, 95% confidence interval (CI) (-0.76, -0.31), P < 0.00001), range of motion (ROM) (MD = 7.24, 95% CI (2.79, 11.69), P = 0.001), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score (MD = -6.91, 95% CI (-9.47, -4.34), P < 0.00001), cartilage recovery (cartilage thickness: MD = 0.43, 95% CI (0.35, 0.51), P < 0.00001; cartilage regeneration: relative risk (RR) = 1.81, 95% CI (1.40, 2.33), P < 0.00001; and the International Cartilage Repair Society (ICRS) grade: RR = 1.96, 95% CI (1.44, 2.66), P < 0.0001), and the Lysholm score (MD = 6.51, 95% CI (4.97, 8.04), P < 0.00001) after HTO-PRP treatment had certain advantages compared to the control group. After treatment, there was no statistically significant difference in the knee joint mechanical axis angle between the HTO-PRP group and the control group (femoral tibial angle (FTA): MD = -0.29, 95% CI (-1.07, 0.49), P = 0.47; medial proximal tibial angle (MPTA): MD = 0.19, 95% CI (-0.49, 0.88), P = 0.58; posterior tibial slope (PTS): MD = -0.12, 95% CI (-0.49, 0.25), P = 0.53; knee varus angle (KVA): MD = -0.30, 95% CI (-1.77, 1.17), P = 0.69; weight-bearing line (WBL): MD = 1.10, 95% CI (-0.89, 3.09), P = 0.28).
CONCLUSION
The results showed that in the treatment of KOA, the HTO-PRP group had better efficacy than the control groups did and had certain safety reliability.
目的
系统评价高胫骨截骨术（HTO）联合富血小板血浆（PRP）治疗膝骨关节炎（KOA）的临床疗效和安全性，为该疾病的循证医学治疗提供证据。
方法
检索 2024 年 9 月前关于 HTO 联合 PRP 治疗 KOA 的临床研究，严格筛选符合纳入标准的文献，提取文献信息，采用 RevMan5.4 进行数据分析。
结果
共纳入 10 项研究（12 个对照），共计 625 例患者。总体而言，视觉模拟评分（VAS）（MD=-0.53，95%CI（-0.76，-0.31），P<0.00001）、关节活动度（ROM）（MD=7.24，95%CI（2.79，11.69），P=0.001）、西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分（MD=-6.91，95%CI（-9.47，-4.34），P<0.00001）、软骨修复（软骨厚度：MD=0.43，95%CI（0.35，0.51），P<0.00001；软骨再生：相对危险度（RR）=1.81，95%CI（1.40，2.33），P<0.00001；国际软骨修复学会（ICRS）分级：RR=1.96，95%CI（1.44，2.66），P<0.0001）和 Lysholm 评分（MD=6.51，95%CI（4.97，8.04），P<0.00001）在 HTO-PRP 治疗后均优于对照组。治疗后，HTO-PRP 组与对照组的膝关节机械轴角度无统计学差异（股骨胫骨角（FTA）：MD=-0.29，95%CI（-1.07，0.49），P=0.47；内侧近端胫骨角（MPTA）：MD=0.19，95%CI（-0.49，0.88），P=0.58；胫骨后倾角（PTS）：MD=-0.12，95%CI（-0.49，0.25），P=0.53；膝关节内翻角（KVA）：MD=-0.30，95%CI（-1.77，1.17），P=0.69；负重线（WBL）：MD=1.10，95%CI（-0.89，3.09），P=0.28）。
结论
结果表明，HTO-PRP 组在治疗 KOA 方面优于对照组，具有一定的安全性和可靠性。
Zotero 插件