Bollag W
Cancer Chemother Pharmacol. 1979;3(4):207-15. doi: 10.1007/BF00254733.
The early and recent investigations in the field of retinoids and cancer are reviewed. The retinoids, including natural vitamin A compounds and their synthetic analogs, present a new class of substances exerting a prophylactic and a therapeutic effect both in certain experimental tumor models and in certain clinical conditions of preneoplastic and neoplastic lesions. Because of a particular physiological mechanism of action, the retinoids offer a new approach to the cancer problem, which is different from those of surgery, X-ray therapy, conventional chemotherapy, and immunotherapy.
本文综述了类视黄醇与癌症领域的早期及近期研究。类视黄醇，包括天然维生素A化合物及其合成类似物，是一类新型物质，在某些实验性肿瘤模型以及某些癌前和肿瘤性病变的临床状况中均具有预防和治疗作用。由于其独特的生理作用机制，类视黄醇为癌症问题提供了一种不同于手术、X射线治疗、传统化疗和免疫治疗的新方法。
