Department of Neuroscience, Faculty of Advanced Medical, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Cell Biochem Funct. 2024 Dec;42(8):e70009. doi: 10.1002/cbf.70009.
Stress refers to an organism's response to environmental threats in normal condition to maintain homeostasis in the body. In addition, strong inflammatory reactions induced by the hypothalamic-pituitary-adrenal (HPA) axis under stress condition during a long time. Reciprocally, chronic stress can induce the irritable bowel syndrome (IBS) which is a well-known gut disorder thereby play an important role in the promotion and pathophysiology of neuropsychiatric diseases. It has been demonstrated that leaky gut is a hallmark of IBS, leads to the entrance the microbiota into the bloodstream and consequent low-grade systemic inflammation. In the current review, we will discuss the mechanisms by which stress can influence the risk and severity of IBS and its relationship with neuroinflammation. Also, the role of probiotics in IBS co-existing with chronic stress conditions is highlighted.
压力是指生物体在正常情况下对环境威胁的反应，以维持体内的内稳态。此外，在压力条件下，下丘脑-垂体-肾上腺（HPA）轴会引发强烈的炎症反应。反过来，慢性压力会导致肠易激综合征（IBS），这是一种众所周知的肠道疾病，从而在神经精神疾病的发生和病理生理学中发挥重要作用。已经证明，肠漏是 IBS 的一个标志，导致微生物群进入血液并随之产生低度全身炎症。在本综述中，我们将讨论压力如何影响 IBS 的风险和严重程度及其与神经炎症的关系。此外，还强调了益生菌在与慢性应激条件共存的 IBS 中的作用。
