Nicholls David G
Buck Institute for Research on Aging, Novato CA, 94945, USA.
Cell Calcium. 2024 Dec;124:102962. doi: 10.1016/j.ceca.2024.102962. Epub 2024 Oct 23.
In a recent publication, Hernansanz-Agusti̒n et al. propose that a sodium gradient across the inner mitochondrial membrane, generated by a Na/H activity integral to Complex I can account for half of the mitochondrial membrane potential. This conflicts with conventional electrophysiological and chemiosmotic understanding.
在最近的一篇出版物中,埃尔南桑斯 - 阿古斯汀等人提出,由复合体I所固有的Na/H活性产生的跨线粒体内膜的钠梯度可占线粒体膜电位的一半。这与传统的电生理和化学渗透理解相冲突。