Do Alison D, Portet Coline, Goutagny Romain, Jackson Jesse
Department of Physiology, University of Alberta, Edmonton, AB, Canada.
University of Strasbourg, Strasbourg, France; Laboratoire de Neurosciences Cognitives et Adaptatives, CNRS UMR7364, Strasbourg, France.
Trends Neurosci. 2024 Dec;47(12):1028-1040. doi: 10.1016/j.tins.2024.10.003. Epub 2024 Nov 2.
Cortical activity is constantly fluctuating between distinct spatiotemporal activity patterns denoted by changes in brain state. States of cortical desynchronization arise during motor generation, increased attention, and high cognitive load. Synchronized brain states comprise spatially widespread, coordinated low-frequency neural activity during rest and sleep when disengaged from the external environment or 'offline'. The claustrum is a small subcortical structure with dense reciprocal connections with the cortex suggesting modulation by, or participation in, brain state regulation. Here, we highlight recent work suggesting that neural activity in the claustrum supports cognitive processes associated with synchronized brain states characterized by increased low-frequency network activity. As an example, we outline how claustrum activity could support episodic memory consolidation during sleep.
皮层活动不断在由脑状态变化所表征的不同时空活动模式之间波动。皮层去同步化状态出现在运动产生、注意力增强和高认知负荷期间。当脱离外部环境或处于“离线”状态时，同步脑状态包括休息和睡眠期间在空间上广泛分布、协调一致的低频神经活动。屏状核是一个小的皮层下结构，与皮层有密集的相互连接，这表明它受到脑状态调节或参与脑状态调节。在这里，我们重点介绍最近的研究工作，这些工作表明屏状核中的神经活动支持与以低频网络活动增加为特征的同步脑状态相关的认知过程。例如，我们概述了屏状核活动如何在睡眠期间支持情景记忆巩固。
